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"Substance Use and Addiction Research: Methodology, Mechanisms, and Therapeutics is an up-to-date, comprehensive, practical book on the research methodology for substance misuse and addiction intended for researchers and consumers of research information at all levels. The book is divided into three major parts: Research Methodology for Clinical Trials, Animal Research, and Retrospective Studies; Mechanisms of Drug Misuse and Addiction; and Investigative Therapeutics: Designing and Measuring Outcomes. It serves as a source that addresses all aspects of research design, methods, and analysis within the context of the field of opioids, alchohol, and other substances. The book discusses in detail the research methods used in designing prevention, screening, pharmacological management, and health services needed for substance misuse and addiction of all major illicit and prescribed drugs, foods, alcohol, and tobacco products. Research design and useful tips are provided for researchers and consumers of the literature, describing various biological methods, specialists, and analytical methods. The background is set up on the development of the discipline in question, its key features and applications, how the methods compare to other methods/analyses, and their advantages and limitations."--Back cover.
List of contents
Basics of Research Methodology 1. Reliability and validity in substance abuse and addiction research
2. Animal models
3. Translational research strategies
4. Experimental design in clinical trials Part 1
5. Experimental design in clinical trials Part 2
6. Qualitative and quantitative methods
7. Ethical issues in opioids, alcohol, other drugs and addiction-related research:
8. Informatics
9. Artificial intelligence and machine learning
10. Epidemiology and health services research methods
11. Imaging
12. Systematic review and meta-analysis
Mechanisms of abuse and addiction 13. Abuse and addiction
14. Assessment of addiction/pain and neurobiology
15. Physiological considerations in opioid addiction
16. Basic pharmacology - opioid substances
17. Basic pharmacology - non-opioid substances
18. Types of addiction
19. Substance use
20. Special study populations
Investigative Therapeutics: Designing studies and measuring outcomes21. General therapy strategies in substance addiction
22. Alternative Therapy Strategies in Addiction
23. Drug testing and adherence monitoring
24. Pharmacogenetics - Genes, genetics, genomics and epigenetics
25. Novel therapeutic strategies effectiveness
26. Methods of psychosocial interventions
27. Principles of vaccine development
28. Drug policy analysis
29. Implementation science: Theories, models and frameworks
30. Designing and testing population-based prevention programs
31. New vistas in research
About the author
Alan David Kaye, MD, PhD, is the Professor and Chairman of the Department of Anesthesiology at LSU Health Sciences Center in New Orleans since January 2005. He is Board Certified as a Consultant in Anesthesiology and has a special certificate in Pain Management for the American Board of Anesthesiology. He is also a Diplomate of the American Board of Pain Medicine and the American Board of Interventional Pain Physicians. His PhD is in pharmacology, and he was awarded first place in the National Student Research Forum as a resident. He has authored or co-authored over 150 abstracts and 200 manuscripts and book chapters in the fields of pulmonary vascular pharmacology and anesthesiology. He serves on a number of national committees including as a National Board of Directors of ASIPP and ABIPP. He is editor-in-chief of the journal Pain Physicians and is on the FDA Advisory Board on Anesthetics and Analgesics.Richard D. Urman, MD, MBA, FASA is a staff anesthesiologist at the Brigham and Women’s Hospital in Boston, MA and Associate Professor of Anesthesia at Harvard Medical School. He currently serves as Associate Chair for Dana-Farber Cancer Institute, as well as Medical Director of Sedation for Interventional Medicine, Director, Center for Perioperative Research (C.P.R.), and Perioperative Medicine Fellowship Director. He is also the founder of the Incubator for Patient Safety and Outcomes (IPSO).
Dr. Urman received his MD from Harvard Medical School and MBA from Harvard Business School, and completed a residency in anesthesia at Beth Israel Deaconess Medical Center. On the national level, Dr. Urman currently serves on various committees of the American Society of Anesthesiologists (ASA) including as Chair of the subcommittee on Patient Safety and Practice Management, Foundation of Anesthesia Education and Research (FAER), Society for Preoperative Assessment and Quality Improvement, and Enhanced Recovery After Surgery-USA.
