Read more
Informationen zum Autor Karl Herrup is Professor of Neurobiology and an Investigator in the Alzheimer's Disease Research Center at the University of Pittsburgh School of Medicine. He is also Adjunct Professor of Life Science at the Hong Kong University of Science and Technology, where he was formerly Head of Life Sciences. Klappentext "A trade book on Alzheimer's disease--its human face, some insights into its biology, the discoveries that seemed a path to prevention if not cure, 25 years without progress, and a new path forward"-- Zusammenfassung An authority on Alzheimer's disease offers a history of past failures and a roadmap that points us in a new direction in our journey to a cure. For decades, some of our best and brightest medical scientists have dedicated themselves to finding a cure for Alzheimer's disease. What happened? Where is the cure? The biggest breakthroughs occurred twenty-five years ago, with little progress since. In How Not to Study a Disease , neurobiologist Karl Herrup explains why the Alzheimer's discoveries of the 1990s didn't bear fruit and maps a direction for future research. Herrup describes the research, explains what's taking so long, and offers an approach for resetting future research. Herrup offers a unique insider's perspective, describing the red flags that science ignored in the rush to find a cure. He is unsparing in calling out the stubbornness, greed, and bad advice that has hamstrung the field, but his final message is a largely optimistic one. Herrup presents a new and sweeping vision of the field that includes a redefinition of the disease and a fresh conceptualization of aging and dementia that asks us to imagine the brain as a series of interconnected "neighborhoods." He calls for changes in virtually every aspect of the Alzheimer's disease research effort, from the drug development process, to the mechanisms of support for basic research, to the often-overlooked role of the scientific media, and more. With How Not to Study a Disease , Herrup provides a roadmap that points us in a new direction in our journey to a cure for Alzheimer's. Inhaltsverzeichnis Prologue ix I In the Beginning 1 1 A Layperson's History of Alzheimer's Disease 3 2 A Physician's History of Alzheimer's Disease 23 3 A Scientist's History of Alzheimer's Disease 33 4 Mystery Solved! How Four Discoveries Transformed an Entire Field 53 II What Happened to our Cure? 71 5 Building a Model of Alzheimer's Disease 73 III Double-Edged Swords 97 6 Federal Support of Basic Biomedical Research 99 7 The Pharmaceutical and Biotech Industry 115 8 Testing Our Models: Breaking Bad 131 9 What is Alzheimer's Disease? 149 IV Where Shall We Go From Here? 169 10 A Layperson's Guide to the Biology of Aging 171 11 Building a New Model of Alzheimer's Disease 187 12 Rebalancing our Research Portfolio 207 13 Rebalancing our Institutions 227 14 Final Thoughts 243 Acknowledgments 247 Notes 249 Index 255...
