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Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included.
This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.
List of contents
1. Mitochondrial physiology: An overview
2. Molecular markers of mitochondrial intoxication
3. Drug-induced mitochondrial impairment: Mechanisms and testing systems
4. Challenges in mitochondrial profiling during pre-clinical studies
5. Acrylamide
6. The effects of air pollution toxicants on the mitochondria
7. Aflatoxin B
8. The effects of the alcohol abuse against the mitochondria. Functional consequences for liver, muscle, and the brain
9. Aluminum
10. Discovery of amiodarone mitochondrial toxicity in liver and beyond
11. Ammonia
12. The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines
13. Anthracycline
14. Antidepressants, mood stabilizing drugs and mitochondrial function; for better or for worse
15. The effects of antiretroviral drugs on the mitochondria
16. Arsenic
17. Mechanisms of bisphenol A toxicity in mitochondria
18. Chemotherapeutic drugs
19. Cuprizone
20. Deltä9¿tetrahydrocannabinol (Cannabis sativa)
21. Diclofenac
22. Food additives
23. Mitochondria as a toxicological target for fungicides
24. The effects of methylglyoxal on the mitochondria
25. The effects of mercury on the mitochondria
26. Organohalogens
27. The effects of organophosphate pesticides on the mitochondria
28. Oxygen toxicity
29. Paracetamol/Acetaminophen
30. Plant molecules (Mitochondrial intoxication induced by plant molecules)
31. Polychlorinated biphenyls (PCBs)
32. The effects of polycyclic aromatic hydrocarbons on the mitochondria
33. Pyrethroids
34. Redox cycling compounds (Mitochondrial toxicity of redox cycling compounds)
35. The effects of sodium nitrate on the mitochondria
36. Zinc
About the author
Marcos Roberto de Oliveira, PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a master’s and a Ph.D. in Biochemistry from the same institution. He is currently a professor and coordinates research at UFRGS. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models.
