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Informationen zum Autor Michael Fromm is the editor of Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257, published by Wiley. Jörg-Dieter Schulzke is the editor of Barriers and Channels Formed by Tight Junction Proteins I, Volume 1257, published by Wiley. Klappentext "Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Certain proteins seal the tight junction, so that a nearly impermeable barrier develops, whereas others form channels that allow for permeation between the cells. Recent investigations have focused on tight junction proteins, belonging to the claudin family (claudins-1 to -27 in humans) and the newly defined group of TAMP (three proteins: occludin, Marvel-D2, and tricellulin). Barriers and Channels Formed by Tight Junction Proteins I showcases work in this area clustered around three major themes: the molecular properties of tight junctions, for example, the role of the claudin family of proteins and the formation of ion and charge-selective channels; the regulation of tight junction and barrier functions via genetic mechanisms and scaffold protein mediation; and the functional role of the tight junction in various tissues, such as the skin, lungs, endothelia, and nervous system"--Publisher description. Zusammenfassung Tight junctions between epithelial and endothelial cells form selective barriers and paracellular channels and regulate paracellular transport of solutes, immune cells, and drugs. More specifically, tight junctions consist of proteins that laterally interconnect neighboring cells of epithelia and endothelia. Inhaltsverzeichnis 1. Perspectives on tight junction research Jörg-Dieter Schulzke, Dorothee Günzel, Lena J. John, and Michael Fromm Molecular properties of the tight junction 20. Charge-selective claudin channel Susanne M. Krug, Dorothee Günzel, Marcel P. Conrad, In-Fah M. Lee, Salah Amasheh, Michael Fromm, and Alan S. L. Yu 29. Claudin-derived peptides are internalized via specific endocytosis pathways Denise Zwanziger, Christian Staat, Anuska V. Andjelkovic, and Ingolf E. Blasig 38. A phosphorylation hotspot within the occluding C-terminal domain Max J. Dörfel and Otmar Huber 45. Determinants contributing to claudin ion channel formation Anna Veshnyakova, Susanne M. Krug, Sebastian L. Mueller, Jörg Piontek, Jonas Protze, Michael Fromm, and Gerd Krause 54. Lipolysis-stimulted lipoprotein receptor: a novel membrane protein of tricellular tight junctions Mikio Furuse, Yukako Oda, Tomohito-Higashi, Noriko Iwamoto, and Sayuri Masuda 59. Overexpression of claudin-5 but not claudin-3 induces formation of trans-interaction-dependent multilamellar bodies Jan Rossa, Dorothea Lorenz, Martina Ringling, Anna Veshnyakova, and Joerg Piontek 67. Association between segments of zonula occludens proteins: live-cell FRET and mass spectrometric analysis Christine Rueckert, Victor Castro, Corinna Gagell, Sebastian Dabrowski, Michael Schümann, Eberhard Krause, Ingolf E. Blasig, and Reiner F. Haseloff 77. Dynamic properties of the tight junction barrier Christopher R. Weber Regulation of the tight junction and barrier function 85. Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells Takashi Kojima and Norimasa Sawada 93. The role for protein tyrosine phosphatase nonreceptor type 2 in regulating autophagosome formation Michael Scharl and Gerhard Rogler 103. Caveolin binds independently to claudin-2 and occluding ...
