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Informationen zum Autor Allan L. Goldstein is professor and Catharine B. & William McCormick Chair of the department of Biochemistry and Molecular Biology at The George Washington University School of Medicine and Health Sciences, where he has served since 1978. He is a world-renowned authority on the thymus gland and the workings of the immune system, and co-discoverer of the thymosins. Dr. Goldstein is the author of over 400 scientific articles in professional journals, the inventor on more than 15 U.S. Patents, and the editor of several books in the fields of biochemistry, biomedicine, immunology and neuroscience. He is on the editorial boards of numerous scientific and medical journals and has been a consultant to many research organizations in industry and government; co-founder of The Institute for Advanced Studies in Aging and Geriatric Medicine, a non-profit research and educational institute; a member of the Board of Trustees of the Albert Sabin Vaccine Institute; and serves as the Chairman of the Board of RegeneRx Biopharmaceuticals. Dr. Goldstein received his B.S. from Wagner College in 1959 and his M.S. and Ph.D. from Rutgers University in 1964. He served as a faculty member of the Albert Einstein College of Medicine from 1964 to 1972, and moved to the University of Texas Medical Branch in Galveston in 1972 as professor and director of the division of Biochemistry. Klappentext The first of two, this volume comprises a collection of papers devoted to the understanding of thymosins--proteins originally isolated from the thymus and possess a unique array of biological properties. Thymosins in Health and Disease I brings together short reviews organized to explore the basic characteristics of these peptides and their hormone-like properties, recent preliminary evidence for their medicinal utility, and a focus on the alpha and beta thymosin families. In particular, Thymosin ß4 (Tß4) holds considerable promise for the treatment of many conditions and diseases. Of note, contributions to this volume include information on the application of thymosins to stem cell differentiation, neurological and cardiovascular regeneration, as well as accounts of thymosins in relation to basic regulatory and cancer cell functions. NOTE: Annals volumes are available for sale as individual books or as a journal. For more information on institutional journal subscriptions, please visit: http: //ordering.onlinelibrary.wiley.com/subs.asp?ref=1749-6632&doi=10.111/(ISSN)1749-6632 ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to Annals online and discounts on print volumes. Please visit http: //www.nyas.org/MemberCenter/Join.aspx for more information on becoming a member. Zusammenfassung The first of two, this volume comprises a collection of papers devoted to the understanding of thymosins proteins originally isolated from the thymus and possess a unique array of biological properties. Inhaltsverzeichnis Introduction for Thymosins in Health and Disease vii Allan L. Goldstein and Enrico Garaci Thymosins: chemistry, genetics, receptors, signaling, and multifunctionality Jack of all trades: thymosin ¿1 and its pleiotropy 1 Luigina Romani, Silvia Moretti, Francesca Fallarino, Silvia Bozza, Loredana Ruggeri, Andrea Casagrande, Franco Aversa, Francesco Bistoni, Andrea Velardi, and Enrico Garaci Single-domain ß-thymosins: the family history 7 John Edwards Controlled delivery of thymosin ß4 for tissue engineering and cardiac regenerative medicine 16 Loraine L. Y. Chiu, Lewis A. Reis, and Milica Radisic Thymosin ¿1 and cancer: action on immune effector and tumor target cells 26 Enrico Garaci, Francesca Pica, Annalu...
