Systems Chemical Biology - Integrating Chemistry and Biology Through Cheminformatics Approaches

Summary

This book will provide a descriptive outline of both the fundamental and the applied aspects of systems chemical biology approaches, focused primarily on the drug discovery context. It will cover a broad range of aspects related to prediction of phenotypic outcome to interfering with key pathways, as well as the design of small molecule modulators aimed at causing a desired phenotype (or to reverse a given diseased phenotype). These relate to both cellular pathways with the goals of understanding and predicting function, and to strategies in multi-drug targeting. This can also be gauged from the rapid growth in the literature in this direction and the creation of new computational/bioinformatics journals.
The book will also provide an overview, with easy-to-understand chapters written by pioneers and leaders in the field, as well as advanced material, to inform the readers of the potential caveats which might be involved in a particular task at hand. It also clearly highlight the scope of Systems Chemical Biology and includes case studies where computational network models have provided experimental insight.

Product details

• Authors: Andreas Bender, Andreas Guha Bender, Rajarshi Guha, Josef Scheiber, Shanmugasundara
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Release: 06.05.2015, delayed
• EAN: 9780470554470
• ISBN: 978-0-470-55447-0
• No. of pages: 300
• Subjects: Natural sciences, medicine, IT, technology > Chemistry; Chemie, Bioinformatik, Life Sciences, Biowissenschaften, Chemische Biologie, chemistry, Bioinformatics & Computational Biology, Biochemie u. Chemische Biologie, Biochemistry (Chemical Biology), Cheminformatik, Chemical Informatics