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Informationen zum Autor Patel! Ramesh N. Klappentext Illustrates the practical advantages and methods for using biocatalysts to produce enantiospecific pharmaceuticals and fine chemicals. This book offers mechanisms for enzyme-catalyzed modification reactions! analyzing syntheses for over 60 brand-name pharmaceuticals. It contains more than 4000 references and 1000 tables! equations! and drawings. Zusammenfassung This book illustrates methods to develop fine chemicals and chiral intermediates used in pharmaceutical, agrochemical, and other biotech applications. International experts detail mechanisms for enzyme-catalyzed modification reactions, analyzing intermediate syntheses for over 60 brand-name pharmaceuticals. They cover instrumentation, solvent se Inhaltsverzeichnis Enzymatic/Microbial Preparation of Chiral Epoxides. Preparation of Optically Active Cyanohydrins using Hydroxynitrile Lyases. High-throughput Biocatalysis for Accelerated Drug Discovery and Development. Enhancing the Stability of Industrial Enzymes. Biocatalytic Hydroxlation Reactions. Dehydrogenases in Synthesis of Chiral Pharmaceuticals. Biocatalysis: Applications and Potentials for the Chemical Industry. Biocatalysis using Enzymes and Microorganisms. Vitamins and Related Compounds: Microbial Production. Biocatalysis in the Preparation of Homochiral Pharamaceuticals. Stereochemistry and Evoluation of Aminotransferases. Chemoenzymatic Synthesis of Chiral Intermediates. Overview of Biocatalysis in Ionic Liquids. Preparative Biotransformations. Directed Evolution and Biocatalysis: Enantioselective Production of Amino Carboxylic Acids. Design! Sequences! and Use of Mutant Haloalkane Dehalogenases. Enantioselective Biocatalysis using Lipases and Esterases. Biocatalysis: Reduction of C=N Bonds. Stereospecific Biocatalytic Epoxidation. Cytochrome P450 BM-3: Directed Evolution & Hydroxylation Reactions. Stereoselective Synthesis of Nucleoside Analogues. Microbial Baeyer-Villiger Oxidations. Developing Novel Biocatalysis for Manufacturing Optically Active Compounds. Enzymatic Asymmetric Synthesis by Decarboxylases. Enzymatic Asymmetric C-C Bond Synthesis. Chemoenzymic Synthesis of Glycophosphopeptides. Recent Advances on Bioreductions Mediated by Baker's Yeast and Other Microorganisms. Biotransformation and Organic Chemistry. Synthesis of Optically Active Pheromones. Microbial Carboxylations in Enantioselective Synthesis. Lipases and Oxynitrilases: Useful Tools in Organic Synthesis. Enzymatic Asymmetric using Aldolases. Enzymatic Racemization and its Application to Synthetic Biotransformations. Amidases and Dehydrogenases in Asymmetric Synthesis. Biocatalysis in Organic Synthesis. Enantiopure Alcohols by Enzymatic Resolution with In-situ Racemization. Engineered Enzyme ...
