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Zusatztext "...will be useful for introducing new workers to these fields! as well as occupying an important place on many reference bookshelves."-- Applied Organometallic Chemistry! Vol 14! 2000 Informationen zum Autor Valery P. Kukhar is the author of Aminophosphonic and Aminophosphinic Acids: Chemistry and Biological Activity, published by Wiley. Harry R. Hudson is the author of Aminophosphonic and Aminophosphinic Acids: Chemistry and Biological Activity, published by Wiley. Klappentext The key role of naturally-occurring amino acids in the chemistry of life and as structural units in peptides, proteins and enzymes has led to intense interest in the chemistry and biological activity of synthetic analogues. The phosphorus analogues of the amino acids have attracted a particular interest in the fields of research directed at the discovery, understanding and modification of physiological processes. Aminophosphonic and Aminophosphinic Acids provides a comprehensive insight into the chemistry and biological activity of these compounds. Separate chapters are devoted to naturally-occurring derivatives, synthetic procedures, structural, spectroscopic and analytical aspects, metal complexes, agrochemicals, neuroactive compounds and biomedical applications and transition-state analogue enzyme inhibitors, with particular emphasis on inhibitors of HIV protease, thrombin and human collagenase. Aminophosphonic and Aminophosphinic Acids is a valuable source of information for researchers working with these types of compounds in biomedical and agrochemical industries and all others working with synthetic analogues of biologically important molecules. Zusammenfassung This text presents all aspects of the chemistry and biological activity of aminophosphinic and aminophosphonic acids and their derivatives including esters and peptides, with emphasis on contemporary research in agrochemical and biomedical applications. Inhaltsverzeichnis Naturally Occurring Aminophosphonic and Aminophosphinic Acids (P. Mastalerz & P. Kafarski). Synthesis of -Aminoalkanephosphonic and -Aminoalkanephosphinic Acids (P. Kafarski & J. Zo). Synthesis of Aminoalkanephosphonic and Aminoalkanephosphinic Acids with the Amino Substituent in Other than the -Position (V. Kukhar). -Amino Acid Analogues Bearing Side-Chain C-P Linkages (S. Lall and R. Engel). Asymmetric Synthesis of Aminophosphonic and Aminophosphinic Acids (V. Kukhar). Synthesis of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejczak). Column Chromatography of Aminophosphonic Acids and Phosphonopeptides (S. Galushko). Physical Properties and NMR-Spectroscopic Characterization of Aminophosphonates and Aminophosphinates (G. Hägele). Structure and Stability Constants of Metal Complexes in Solution (T. Kiss & I. Lázár). X-Ray Crystallographic Studies (N. Choi & M. McPartlin). Mass Spectrometry and Gas Chromatography-Mass Spectrometry of Aminoalkanephosphonic Acids (Z. Kudzin & M. Sochaki). The Biological Activity of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejezak). Aminophosphonic and Aminophosphinic Acids and their Derivatives as Agrochemicals (H. Hudson). Neuroactive Aminophosphonic and Aminophosphinic Acid Derivatives (D. Jane). Aminophosphonic and Aminophosphinic Acid Derivatives in the Design of Transition State Analogue Inhibitors: Biomedical Opportunities and Limitations (J. Oleksyszyn). Aminophosphonic and Aminophosphinic Acids in the Design and Synthesis of HIV Protease Inhibitors (A. Peyman). Aminophosphonic Acid Derivatives as Antithrombotic Agents (D. Green, et al.). Aminophosphonic and Aminophosphinic Acid Derivatives as Inhibitors of Human Collagenase (R. Markwell). Index....
