Progress in the Chemistry of Organic Natural Products 115

This book describes current understandings and recent progress into a varied group of natural products. In the first chapter the role that total synthesis may play in revising the structures proposed for decanolides, which are ten-membered lactones found primarily in fungi, frogs, and termites is presented. The following chapter presents the development of the intriguing plant-derived sesquiterpene lactone, thapsigargin, a potent inhibitor of the enzyme, SERCA (sarco-endoplasmic Ca²⁺ ATPase), which has potential as a lead compound to treat cancer. The third chapter covers the potential of various plant phenolic compounds for treating the tropical and sub-tropical infectious disease, leishmaniasis. In addition the volume presents recent advances related to the plant alkaloid, cryptolepine, which is of particular interest as a lead for the treatment of malaria, trypanosomiasis, and cancer.

List of contents

Total Synthesis of Decanolides (Nonanolides) with a Special Focus on Olefin Metathesis.- From Plant to Patient: Thapsigargin.- Antileishmanial Activity of Lignans and Neolignans.- Cryptolepine as a Lead to new Antiprotozoal Agents.- Biologically Active Constituents from Plants of the Genus Xanthium.

Product details

• Assisted by: Yoshinori Asakawa (Editor), Verena M. Dirsch (Editor), Heinz Falk (Editor), Simon Gibbons (Editor), Simon Gibbons et al (Editor), A. Douglas Kinghorn (Editor), Ji-Kai Liu (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 01.01.2022
• EAN: 9783030648558
• ISBN: 978-3-0-3064855-8
• No. of pages: 203
• Dimensions: 155 mm x 11 mm x 235 mm
• Illustrations: VII, 203 p. 144 illus., 42 illus. in color.
• Series: Progress in the Chemistry of Organic Natural Products
• Subject: Natural sciences, medicine, IT, technology > Biology > Biochemistry, biophysics