Chemical Genomics - Smal Molecule Probes to Study Cellular Function

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

List of contents

Chemogenomics in Drug Discovery.- Chemogenomics Strategies for GPCR Hit Finding.- Chemogenomics Approaches to GPCR Lead Finding.- Diversity-Oriented Synthesis: A Challenge for Synthetic Chemists.- Probing Protein Function with Small Molecules.- Tamoxifen-Based Probes for the Study of Estrogen Receptor-Mediated Transcription.- Protein Structure Similarity Clustering (PSSC) and Natural Product Structure as Guiding Principles for Chemical Genomics.- Novel Strategies in Drug Discovery: Current Challenges in Biomolecular Screening.

About the author

Hilmar Weinmann studied Chemistry at the universities of Tübingen and Hannover (Germany). He joined Schering in 1995, where he is currently a department head of Medicinal Chemistry. His main fields of expertise are in oncology, dermatology and gender healthcare.

Summary

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.

Product details

• Assisted by: S. Jaroch (Editor), Stefa Jaroch (Editor), Stefan Jaroch (Editor), Weinmann (Editor), Weinmann (Editor), H. Weinmann (Editor), Hilmar Weinmann (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 25.04.2006
• EAN: 9783540278658
• ISBN: 978-3-540-27865-8
• No. of pages: 179
• Dimensions: 148 mm x 216 mm x 17 mm
• Weight: 384 g
• Illustrations: XIV, 179 p.
• Series: Ernst Schering Research Foundation Workshop; Ernst Schering Foundation Symposium Proceedings; Ernst Schering Foundation Symposium Proceedings; Ernst Schering Research Foundation Workshop
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Biochemie, C, Medicine, Medical research, ORGANIC CHEMISTRY, Life Sciences, Medizinische Forschung, biochemistry, molecular biology, Chemistry and Materials Science, Pharmacology, Biochemistry, general, Biomedicine, general, Biomedical Research, Molecular Medicine, Pharmacology/Toxicology, MEDICINAL CHEMISTRY