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Preceded by: Handbook of epigenetics / edited by Trygve O. Tollefsbol. Second edition. [2017].
List of contents
1. Epigenetics Overview
SECTION I: Molecular Mechanisms of Epigenetics2. Mechanisms of DNA Methylation and Demethylation during Mammalian Development
3. Mechanisms of Histone Modification
4. The Epigenetics of Non-coding RNA
5. Prions and Prion-like Phenomena in Epigenetic Inheritance
6. Higher-order Chromatin Organization in Diseases
7. Polycomb-group Proteins and Epigenetic Control of Gene Activity
SECTION II: Methods in Epigenetics8. Methods for Assessing DNA Cytosine Modifications Genome-wide
9. Analyses of Genome-wide Histone Modifications in the Mammalian Genome
10. Techniques for Genome-wide Expression of Non-coding RNA
11. Computational Epigenetics
SECTION III: Model Organisms of Epigenetics
12. Epigenetics of Lower Organisms
13. Drosophila Epigenetics
14. Models of Mouse Epigenetic Inheritance: Classification, Mechanisms, and Experimental Strategies
15. Plant Epigenomics
SECTION IV: Factors Influencing Epigenetic Changes16. Dynamic Changes in Epigenetic Modifications During Mammalian Transitions
17. Epigenetic Biomarkers
18. Transposable elements shaping the epigenome
19. Metabolic Regulation of DNA Methylation in Mammalian Cells
20. Dietary and Metabolic Compounds Affecting Covalent Histone Modifications
21. Epigenetics, Stem Cells and Cellular Differentiation
22. Regeneration Epigenetics
23. Epigenetics of X-chromosome Inactivation
24. Epigenetics of Memory Processes
25. Transgenerational Epigenetics
26. DNA Methylation Clocks in Age-related Disease
SECTION V: Evolutionary Epigenetics27. Evolution of Epigenetic Mechanisms in Plants
28. Evolution of Epigenetic Mechanisms in Animals and Their Role in Speciation
29. Adaptive Evolution and Epigenetics
SECTION VI: Epigenetic Epidemiology30. Epigenetics of Livestock Breeding
31. Nutritional Epigenetics and Metabolic Syndrome
32. Epigenetics of Drug Addiction
33. Environmental Influence of Epigenetics
34. The Gut Microbiota Influence on Human Epigenetics, Health and Disease
35. Population Pharmacoepigenomics
SECTION VII: Epigenetics and Human Disease36. Cancer Epigenetics
37. The Role of Epigenetics in Autoimmune Disorders
38. Epigenetics of Brain Disorders
39. The Epigenetics of Metabolic Diseases
40. Imprinting Disorders in Humans
SECTION VIII: Epigenetic Therapy41. DNA Demethylating Agents in Clinical Medicine
42. Clinical Applications of Histone Deacetylase Inhibitors
43. Combination Epigenetic Therapy
SECTION XI: The Future of Epigenetics44. New Directions for Epigenetic Research: Application of Engineered DNA-binding Molecules to Locus-specific Epigenetic Research
About the author
Dr. Tollefsbol is a Distinguished Professor at the University of Alabama at Birmingham. He holds doctorates in molecular biology and osteopathic medicine, trained with National Academy of Science members and has over 200 peer-reviewed publications. Reports highlighting the translatability to the lay public of the discoveries made in his laboratory have appeared in international media representing >50 million readers. Dr. Tollefsbol has been featured as an Investigator in the Spotlight by the NIH as well as a Scientist in the Spotlight by ScienceNow. He is an Associate Editor for Frontiers in Genetics, a contributor to Lewin’s GENES classic textbook and Lead Editor for Elsevier’s Translational Epigenetics Series. Dr. Tollefsbol has been named a “Highly Ranked Scholar” worldwide (ScholarGPS). He has been invited for numerous endowed keynote presentations, his research has been highlighted in eScience News and ScienceDaily and he has published 20 scholarly books on topics related to his research.
