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This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing.
Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.
List of contents
Chapter 1: Historical Perspective of Drug Discovery and Development.- Chapter2: Natural Products and Drug Discovery.- Chapter 3: The Concept Of Receptors And Molecules Interaction In Drug Discovery And Development.- Chapter 4: Chemical Structure and Stereochemistry.- Chapter 5:Biased Agonism:Renewing GPCR's targetability.- Chapter 6: Computer Aided Drug Discovery.- Chapter 7: Pharmacological screening of novel chemical entities.- Chapter 8:Drug Target Identification and Validation.- Chapter 9: Genetics and Drug Discovery.- Chapter 10: Stem Cells and Therapeutics.- Chapter 11: Pharmacokinetics.- Chapter 12: Regulatory Toxicological Testing.- Chapter 13: Nanotoxicology and Regulatory Requirements.- Chapter 14: Clinical Trials in Industrial Drug Development.- Chapter 15:Pharmacovigilance.- Chapter 16: Regulatory Process for New Drug Approval in India.- Chapter 17: Pharma Industry, Academia, Regulatory Authorities, and End-user Interaction.- Chapter 18: Statistics.
About the author
Dr. Ramarao Poduri, M Pharm, PhD, is currently working as Dean of Academic Affairs, Dean of the School of Basic and Applied Sciences, and a Professor at the Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab, Bathinda, India. Dr. Poduri graduated from the Banaras Hindu University of India and completed his postdoctoral research at the University of Illinois, Chicago and Harvard Medical School, Boston. With more than 40 years of teaching experience, he has worked at various prestigious institutes, including Banaras Hindu University, NIPER, S.A.S. Nagar and the Central University of Punjab. Dr. Poduri has published more than 140 peer-reviewed research papers and received e.g. the ISCB Award for Excellence (2009), Indian Society of Chemists & Biologists Pharma-Bio Award (2009), and IASTAM Dr. K.M. Parikh Award (2018).
