Chemical and Structural Approaches to Rational Drug Design

This book is the first to provide both a broad overview of the current methodologies being applied to drug design and in-depth analyses of progress in specific fields. It details state-of-the-art approaches to pharmaceutical development currently used by some of the world's foremost laboratories. The book features contributors from a variety of fields, new techniques, previously unpublished data, and extensive reference lists.

List of contents

Section I: Chemical Approaches to Rational Drug Design 1. Design, Synthesis and Antitumor Activity of an Inhibitor of Ribonucleotide Reductase 2. The Development of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitors 3. The Development of Potent Angiotensin II Receptor Antagonists Using a Novel Peptide Pharmacophore Model 4. Endothelin Structure and Development of Receptor Antagonists 5. Molecular Targeting Chemistry in Rational Drug Design Section II: Structural Approaches to Rational Drug Design 6. The Role of X-Ray Crystallography in Structure-Based Rational Drug Design 7. Biocomputational Approaches to Protein-Based Drug Design 8. Architecture and Design of Zinc Protein-Ligand Complexes 9. Design of Immunomodulatory Peptides Based on Active Site Structures

About the author

Weiner\, David B.; Williams\, William V.

Summary

This book deals with predominantly synthetic chemical approaches to drug design and explores the use of structure-activity relationships in the design of novel inhibitors of ribonucleotide reductase. It describes the application of the tools of structural biology to pharmaceutical development.

Product details

• Authors: James McCarthy
• Assisted by: David B. Weiner (Editor), Weiner David B. (Editor), William B. Williams (Editor), William V. Williams (Editor), Williams William V. (Editor), Mannfred A. Hollinger (Editor of the series)
• Publisher: Taylor and Francis
• Languages: English
• Product format: Hardback
• Released: 28.11.1994
• EAN: 9780849378188
• ISBN: 978-0-8493-7818-8
• No. of pages: 290
• Weight: 680 g
• Illustrations: schwarz-weiss Illustrationen, Raster,schwarz-weiss, Tabellen, schwarz-weiss
• Series: Handbooks in Pharmacology and Toxicology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; MEDICAL / Pharmacology, Pharmacology, Pharmaceutical technology, Pharmaceutical chemistry and technology, TECHNOLOGY & ENGINEERING / Pharmaceutical