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Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion.
The book also considers the impact of aging within the immune system, the relationship between aging and diseases such as cancers and neurodegenerative conditions, and provides an overview on the dialogue surrounding the topic of aging beyond basic biology.
List of contents
1. Decoding the mystery of ageing and the hallmarks of ageing
Section I. The Genome
2. Epigenetic ageing and its reversal
Section II. Metabolism, Homeostasis and Communication
3. Nutrient sensing and aging
4. Dysregulated proteostasis
Section III. Autophagy and Bioenergetics
5. Autophagy and bioenergetics in aging
Section IV. Senescence
6. Senescence in Ageing
Section V. Applications
7. Ageing and the immune system
8. Canonical and novel strategies to delay or reverse ageing
About the author
Evandro Fei Fang is a molecular gerontologist and is currently Associate Professor at the Department of Clinical Molecular Biology, University of Oslo and the Akershus University Hospital, Norway. He has an extensive track record of mechanistic studies on human aging and mitophagy, and his main research interests currently center on exploring the basic molecular mechanisms of human ageing and age-related diseases, with a final goal to develop interventional strategies to improve people's lifespan and healthspan. He is currently pursuing the development of novel anti-ageing compounds using artificial intelligence combined with a cross-species wet-lab validation. Dr. Fang is also co-founder of the Norwegian Centre on Healthy Ageing (NO-Age) and the Norwegian anti-Alzheimer’s disease (NO-AD) networks.Linda Bergersen is Professor and Dean of Research at the Faculty of Dentistry, University of Oslo, Norway, and also serves as Professor of Neurobiology of Aging at the Center of Healthy Aging (CEHA), University of Copenhagen, Denmark. She is also a former athlete who specializes in understanding the link between physical exercise and prevention of neurodegenerative disease. Dr. Bergersen has pioneered the study of how exercise can improve brain health and has expanded from there into further aging fields. She has received a number of awards and fellowships for her research and is also co-founder of the Norwegian Centre for Healthy Ageing (NO-Age).Brian Christopher Gilmour is currently a PhD candidate in medicine at the University of Oslo, Norway. Aiming to develop a research career in aging, he is well-acquainted with the functions of the immune system and looking to further develop the relation between the immune system and human aging. He works closely with the Norwegian Centre for Healthy Ageing (NO-Age).
Report
"This comprehensive book .is a very worthy endeavor . [U]nderstanding the factors that lead to age-related biological changes and associated diseases is critically important to advancing medical treatment . [It] emphasizes lifestyle modification and healthy living practices, which is welcome . [P]rovides an overview of the various molecular and cellular theories of aging physiology and pathology, . [examining] genetics, protein-related processes, immune system principles, calorie reduction, and other theories believed to underlie biological changes in human aging, ultimately leading to senescence and death . This book is very good well written and researched, and covers a wide range of topics without any significant omissions. [A]chieves its goals with good use of figures/images which are nicely done." --©Doody s Review Service, 2023, Belinda Setters, MD, MS, FACP, AGSF (Robley Rex VA Medical Center)
