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Pal, K Pal, Kaushik Pal, Kaushik Pal, Pal Kaushik
Nanovaccinology As Targeted Therapeutics
English · Hardback
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Description
NANOVACCINOLOGY AS TARGETED THERAPEUTICS
The book presents the early-stage development of nanovaccines that could well be the new generation of vaccines which have a great potential for the prevention and treatment of many diseases.
Nanovaccinology as Targeted Therapeutics explores recent breakthroughs in the exciting new field of micro- and nanofabricated engineered nanomaterials. In addition to spectroscopic characterizations, significant topics for interdisciplinary research, especially in the fields of nanogels, which deal with polymer chemistry, nanotechnology, materials science, pharmaceuticals, and medicine are explored, where their small dimensions prove highly advantageous. Nanovaccinology could potentially revolutionize conventional therapy and diagnostic methods due to its superior effectiveness over its macro-sized counterparts in almost all biomedical areas. Strong interest in this novel class of material has driven many studies to discover biogenic production methods and new areas of potential utilization in this area. Therefore, it is important to keep abreast of the development of these biomedical research aspects highlighted in the 19 chapters of this book written in diverse fields of studies, and their emerging applications utilized in next-generation techniques.
Audience
Biotechnologists, nanotechnologists, materials scientists, biochemists, medical biologists, drug delivery and formulation chemists, virologists and pharmacists.
List of contents
Preface xv
1 Nanotechnology in Vaccine Development and Constraints 1
Tahmina Foyez and Abu Bin Imran
1.1 Introduction 2
1.2 Nanoparticles, an Alternative Approach to Conventional Vaccines 4
1.3 Nanoparticles as Vaccine Delivery Vehicle 5
1.4 Nanotechnology to Tackle the Challenges of Vaccine Delivery 6
1.4.1 Polymeric Nanoparticles 6
1.4.2 Inorganic Nanoparticles 7
1.4.3 Biomolecular Nanoparticles 8
1.4.4 Liposome 9
1.4.5 Virus-Like Particles 9
1.4.6 Micelles 9
1.4.7 Immunostimulating Complexes 10
1.4.8 Self-Assembled Proteins (SAPNs) 10
1.4.9 Emulsions 11
1.5 Constraints and Challenges of Nanovaccines 11
1.6 Concluding Remarks 12
Acknowledgments 13
References 13
2 Nanomedicine and Nanovaccinology Tools in Targeted Drug Delivery 21
Bogala Mallikharjuna Reddy
2.1 Introduction 21
2.2 Nanomaterial-Based Drug Delivery Tools 25
2.2.1 Inorganic Nanoparticles 26
2.2.2 Polymeric Nanoparticles 26
2.2.3 Dendrimers 27
2.2.4 Liposomes 28
2.2.5 Micelles 29
2.2.6 Emulsions 30
2.2.7 Carbon-Based Nanomaterials 30
2.2.8 Self-Assembled Proteins 31
2.2.9 Immunostimulating Complexes 32
2.2.10 Virus-Like Particles 33
2.3 Targeted Drug Delivery Applications 33
2.3.1 Cancer 36
2.3.2 Neurology 37
2.3.3 Cardiology 38
2.3.4 Ophthalmology 38
2.3.5 Pulmonology 39
2.3.6 Tissue Engineering 40
2.3.7 Viral Infections 40
2.3.8 Other Miscellaneous Types 41
2.4 Commercial Nanodelivery Tools 42
2.4.1 Industrial Manufacturing 42
2.4.2 Advantages and Disadvantages 44
2.4.3 Risks and Challenges 45
2.5 Conclusions and Future Prospects 46
Acknowledgments 47
References 47
3 Nanovaccinology and Superbugs 53
Sandhya Kalathilparambil Santhosh, Kaviya Parampath Kootery, Mridul Umesh, Preethi Mariam Alex, Meghna Mani, Adina Roy and Suma Sarojini
3.1 Introduction 54
3.2 Need for Nanovaccines 55
3.3 Types of Nanovaccines 57
3.3.1 Subunit Vaccines 57
3.3.2 Conjugate Vaccines 58
3.3.3 RNA Vaccines 58
3.3.4 Reverse Vaccinology 59
3.3.5 Biomimetic Nanovaccines 60
3.3.5.1 Biomimetic Membranes 60
3.3.5.2 Outer Membrane Vesicle Nanoparticles 61
3.3.6 Nanotoxoids 62
3.3.7 Liposomes 63
3.3.8 Polymeric Nanoparticles 63
3.3.9 Virus-Like Particle 64
3.3.10 Inorganic Nanoparticles 65
3.4 Mechanism of Action of Nanovaccines 65
3.5 Limitations of Nanovaccines 68
3.6 Conclusion 69
Acknowledgment 69
References 69
4 Current Research Trends on SARS-CoV2 Virus Against Nanovaccine Formulation 77
Pushpalatha C., Chhaya Kumar, Sowmya S.V., Dominic Augustine, Elizabeth Abbu Varghese and Jithya Suresh
4.1 Introduction 78
4.2 COVID-19/SARS-CoV2 Pathophysiology 78
4.3 Development of Nanovaccines Against SARS-CoV 2 79
4.4 Biomimetic Nanovaccines Against SARS-CoV 2 80
4.4.1 Virus-Like Particles 84
4.4.2 Nucleic Acids Vaccines 85
4.4.3 Protein Vaccines 86
4.5 Translatable Subunit Nanovaccine Against SARS-CoV 2 86
4.6 Separable Microneedle Patch Nanovaccine 86
4.7 Polymer-Based Nanovaccines 87
4.8 Pharmaceutical Challenges of SARS-CoV2 Nanovaccines 88
4.9 Futur
About the author
Kaushik Pal received his PhD from the University of Kalyani. India in 2014. He is now at the University Centre for Research and Development (UCRD), Chandigarh University, Gharuan, Mohali, Punjab. He has published more than 120 research articles in international journals as well as 23 books. He was recently awarded Honoris Causa Doctor of Science (D.Sc.) from Higher National Youth Skills Institute (IKTBN) Sepang, Govt. of Malaysia as well as the Gold Medal awarded by the Prime Minister of Malaysia.
Summary
NANOVACCINOLOGY AS TARGETED THERAPEUTICS
The book presents the early-stage development of nanovaccines that could well be the new generation of vaccines which have a great potential for the prevention and treatment of many diseases.
Nanovaccinology as Targeted Therapeutics explores recent breakthroughs in the exciting new field of micro- and nanofabricated engineered nanomaterials. In addition to spectroscopic characterizations, significant topics for interdisciplinary research, especially in the fields of nanogels, which deal with polymer chemistry, nanotechnology, materials science, pharmaceuticals, and medicine are explored, where their small dimensions prove highly advantageous. Nanovaccinology could potentially revolutionize conventional therapy and diagnostic methods due to its superior effectiveness over its macro-sized counterparts in almost all biomedical areas. Strong interest in this novel class of material has driven many studies to discover biogenic production methods and new areas of potential utilization in this area. Therefore, it is important to keep abreast of the development of these biomedical research aspects highlighted in the 19 chapters of this book written in diverse fields of studies, and their emerging applications utilized in next-generation techniques.
Audience
Biotechnologists, nanotechnologists, materials scientists, biochemists, medical biologists, drug delivery and formulation chemists, virologists and pharmacists.
Product details
Authors | Pal, K Pal, Kaushik Pal |
Assisted by | Kaushik Pal (Editor), Pal Kaushik (Editor) |
Publisher | Wiley, John and Sons Ltd |
Languages | English |
Product format | Hardback |
Released | 31.05.2022 |
EAN | 9781119857341 |
ISBN | 978-1-119-85734-1 |
No. of pages | 352 |
Subjects |
Natural sciences, medicine, IT, technology
> Physics, astronomy
> Atomic physics, nuclear physics
Nanotechnologie, Medizin, Immunologie, Immunology, Nanotechnology, Medical Science, Nanobiotechnologie, Nanobiotechnology |
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