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Informationen zum Autor Néstor Gálvez-Jiménez is Chairman of the Department of Neurology, Cleveland Clinic Florida, Weston, FL, USA. Amos D. Korczyn is an emeritus Professor of Neurology at Tel Aviv University, Tel-Aviv, Israel. He was the incumbent of the Sieratzki Chair of Neurology at Tel-Aviv University, and the Chairman of the Department of Neurology at the Tel-Aviv Medical Center since 1981 until 2002. Ramón Lugo-Sanchez is a clinican on the Movement Disorders Program in the Department of Neurology, Cleveland Clinic Florida, Weston, FL, USA. Klappentext "1. Introduction Non-motor symptoms (NMS) are a crucial component of Parkinson's disease (PD) and the burden of the range of NMS that occurs in PD is one of the main determinants of quality of life [1]. In 1817, Dr James Parkinson already described several NMS in his "shaking palsy", the condition that would later be named after him, including pain, constipation and sleep disturbances [2]. Nonetheless, after a long period of inertia, over the last 20 to 25 years the interest in NMS has increased and evidence suggests that the overall burden of NMS dominates and can influence the risk of developing motor parkinsonism in the premotor stage of PD while being a driving factor for quality of life [3]. The identification of NMS in PD has been greatly aided by the development of specific tools, such as the NMS questionnaire (NMSQ) in 2006 [4] and the NMS Scale (NMSS) in 2007 [5]. The NMSS, which was based on the previously validated NMSQ, addresses a wide range of NMS in PD which are grouped into nine domains, measured over the period of the last month and quantified by severity and frequency (NMS symptomatic burden) [5]. Recently, a new version of the NMSS, the Movement Disorder society - Non-motor symptoms scale (MDS-NMS), has been published which will further aid in the identification and quantification on NMS burden of PD [6]. In this chapter, we will describe the phenomenology of NMS in PD, including non-motor fluctuations (NMF), and how to measure these symptoms"-- Zusammenfassung A comprehensive and practical manual describing the manifestations, pathophysiology and treatments for non-motor Parkinson's Disease. Topics covered in depth include autonomic and sexual dysfunction, mood disorders, sleep disturbances and drug-induced non-motor symptoms. Inhaltsverzeichnis Introduction; 1. Parkinson's disease: an overview of non-motor symptomatology Valentina Leta, Daniel van Wamelen and Ray Chaudhuri; 2. Evaluation of the patient with Parkinson's disease in the early stages: non-motor phase Anna Sauerbier, Daniele Urso, Chloe Farrell, K. Ray Chaudhuri and Carmen Rodriguez-Blazquez; 3. Non-motor symptoms in late-stage Parkinson's disease Umar Shuaib, Adam Margolius and Hubert Fernandez; 4. Neuropathology of non-motor Parkinson's disease symptoms Lea Grinberg and Helmut Heinsen; 5. Neuroimaging studies in non-motor Parkinson's disease symptoms David Brooks; 6. Mild cognitive impairment Amos D. Korczyn; 7. Cognitive dysfunction in Parkinson's disease Damon Salzman and Shakeel Tabish; 8. Neuropsychiatric (behavioral) symptoms in Parkinson's disease Kasia Rothenberg; 9. Mood disorders in patients with Parkinson's disease Po-Heng Tsai and Ganesh Gopalakrishna; 10. Olfactory dysfunction in Parkinson's disease and related disorders Richard Doty and Christopher Hawkes; 11. Oculomotor and visual-vestibular disturbances in Parkinson's disease Adolfo Bronstein, Aasef Shaikh, Tim Anderson, Michael MacAskill and Diego Kaski; 12. Autonomic dysfunction and failure in Parkinson's disease Thomas Foki, Birgit Riemer, Bianca Brim and Walter Struhal; 13. Gastrointestinal disturbances in Parkinson's disease, including the management of Sialorrhea Wolfgang H. Jost and Lisa Klingelhoefer; 14. Sexual dysfunction in Parkinson's disease Gila Bronner and Tanya Gurevich; 15. Sleep disturbances in Parkinson's disease, including rapid eye movement behavior disorde...
