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Xenobiotics in Chemical Carcinogenesis: Translational Aspects in Toxicology covers the translational toxicology of xenobiotics substances in carcinogenesis by explaining the toxicokinetic and toxicodynamic, toxicogenomic, biotransformation, and resistance mechanisms in the human body. The book begins with a historical review and link to future prospects for chemical carcinogenesis. It discusses major environmental xenobiotics and their risks in inducing cancer, along with content on toxic xenobiotics and their routes of exposure in humans, the role of xenobiotic metabolism in carcinogenesis, and the toxicokinetic and toxicodynamic of xenobiotics in cancer development.
Lastly, the book explores current achievements such as using toxicogenomics for predicting the carcinogenicity of xenobiotic substances and the challenges posed by carcinogenic xenobiotic substances when examining preventive methods, diagnosis, and the development of anticancer drugs for specific toxicants.
List of contents
1. A historical review and future prospective of chemical carcinogenesis
2. Role of xenobiotics metabolism in carcinogenesis
3. Recalcitrant of toxic xenobiotics and its routes of exposure to human
4. Major environmental xenobiotics risk for different cancers
5. Toxicokinetic and toxicodynamic of xenobiotics in cancer development
6. Mechanism of oxidative stress in carcinogenesis induced by xenobiotics
7. Genotoxic and non-genotoxic activities of cancer-inducing xenobiotics
8. Modulation of epigenome by xenobiotics in cancer
9. Carcinogenic effects of nanomaterials with emphasis on nanoplastics
10. Endocrine disruptor activity of xenobiotics in carcinogenesis
11. Environmental exposures (Bisphenol A and phatalates) as xenoestrogens enhance risk for breast cancer
12. Biotransformation of toxic xenobiotics by human gut microbiota
13. Mechanism of resistance to toxic xenobiotics in human
14. Profiling the reactive metabolites of xenobiotics in cancer
15. Toxicogenomic for prediction of carcinogenicity of xenobiotic substances
About the author
Dr. Akhileshwar Kumar Srivastava works as a Research Associate (ICMR) at CSIR-Central Food Technological Research Institute, Mysore, India. In his 11 years of research, he has published more than 18 research articles in reputed international journals, along with 4 books and 11 book chapters. His research specialization is primarily in the area of pharmacognosy with genetics, metabolomics, bioinformatics, and molecular biology associated with targeting virulent factors of diseases. In addition, he has studied at Augusta University (formerly, Georgia Regents University) in Augusta, GA, USA, on a J-1 Exchange Scholar Visa and at Ben-Gurion University, Israel. He is also a life member fellow in the Indian Science Congress and the Agriculture, Nutrition and Health Academy, UK.
