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Cholesterol Metabolism in Aging and Disease provides in-depth coverage on the mechanistic intersection between the aging process and cholesterol metabolism. The book covers the discovery of cholesterol, its biochemistry, and how it came to have such a prominent role in aging and disease. Important areas such as cholesterol biosynthesis and cellular cholesterol homeostasis are described in detail. Technological advancements in computational modeling are also discussed to help improve our understanding of cholesterol metabolism so that new therapeutic avenues are opened to help treat age-related diseases associated with the dysregulation of this key system. This is a must have reference for students and researchers interested in, or working in, various aspects of aging. In addition, it is ideal for clinician researchers and gerontologists.
List of contents
1. Introduction
2. The role of Cholesterol in the Body
3. The Cholesterol Biosynthesis Pathway
4. Maintaining intracellular Cholesterol Homeostasis
5. The regulation of whole body Cholesterol Metabolism
6. How does aging impact Cholesterol Metabolism?
7. Cholesterol metabolism and Cardiovascular Disease
8. Cholesterol Metabolism and Cancer
9. Cholesterol Metabolism and Alzheimer's Disease
10. Cholesterol Metabolism in the Oldest old
11. How Diet and Alcohol influences Cholesterol Metabolism
12. Computational Models of Cholesterol metabolism
About the author
Mark Mc Auley, PhD, is senior lecturer in chemical engineering at the University of Chester. He completed his PhD entitled “Systems Modelling of Human Ageing” under the tutelage of Professor Tom Kirkwood, CBE, an internationally acclaimed ageing researcher and Professor Darren Wilkinson an internationally renowned researcher in statistics.
His teaching centers on applied biochemistry, biotechnology, molecular biology and bioinformatics. Mark has over 15 years’ experience of applying computing to challenges in bioscience. He uses computational modelling to help improve our understanding of complex biochemical pathways and research centers primarily on the ageing process. He has published over 30 peer-reviewed articles in the area of health, aging and nutrition.
