Fr. 119.00

Biomolecular Interactions, and Anticancer Activity of Ni, Pd and Ru - Complexes Bearing Heterocyclic Thiosemicarbazone Ligands

English · Paperback / Softback

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Description

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Metalloanticancer drug discovery remains one of the progressive areas driving pharmaceutical research. The wide assortment of coordination numbers and geometries, accessible redox states, thermodynamic and kinetic characteristics, and the intrinsic properties of metal ion and ligand offer the medicinal chemist a large diversity of reactivities to be exploited.The modern era of metal-based anticancer drugs began with the discovery of cisplatin by Barnett Rosenberg in the 1960s. The widespread success of metallodrug cisplatin enticed a veritable army of inorganic chemists to search for other metal-based drugs. Although highly effective in treating a variety of cancer, they suffer from two main disadvantages: they are inefficient against platinum-resistant tumors and they have severe side effects such as neuro-, hepto- and nephrotoxicity. These problems have stimulated an extensive search and prompted chemists to develop alternative strategies based on different metals. Hence, the work to find more efficacious, target specific, less toxic and non-covalently binding DNA targeting drugs bearing metal ions other than platinum is quite significant.

About the author










Dr. J. Haribabu was born on 26th June 1989 in Andhra Pradesh, India. He did B.Sc., Chemistry in Sri Venkateswara University, Tirupathi and M.Sc., Chemistry in Vellore Institute of Technology, Vellore. He has obtained his Ph.D., in bioinorganic and organometallic chemistry from National Institute of Technology, Tiruchirappalli, India in 2018.

Product details

Authors Jebiti Haribabu, Kumaramangalam Jeyalakshmi, Ramasamy Karvembu
Publisher LAP Lambert Academic Publishing
 
Languages English
Product format Paperback / Softback
Released 01.01.2021
 
EAN 9786204190150
ISBN 9786204190150
No. of pages 392
Subject Natural sciences, medicine, IT, technology > Chemistry > Inorganic chemistry

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