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Atopic dermatitis (eczema) is one of the most common and most challenging skin conditions, for patients and practitioners alike. Uniquely organized by intrinsic and extrinsic etiologies, Atopic Dermatitis: Inside Out or Outside In? examines a myriad of causes that start from both the inside of the body and from the external environment, offering physicians practical ways to design treatments that specifically address these causes. Drs. Lawrence S. Chan and Vivian Y. Shi, along with a team of expert contributing authors, examine the etiology of this complex disorder and provide targeted, comprehensive solutions and the most useful therapeutic plans based on pathophysiology, including evidence-based integrative management. Analyzes the pathophysiology of atopic dermatitis from two distinct fronts: inside out and outside in-an approach that is unique in the field. Begins with an overview of the disease, then delves into both internal and external pathogenic factors, followed by the Clinician's Corner, which offers practical recommendations for treatment. Organizes therapeutic discussions by corresponding pathophysiology rather than a one-size-fits-all approach. Covers recently FDA-approved and emerging medications, as well as atopic comorbidities. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
List of contents
Section I: A History of Atopy1 Historic Perspective
2 Atopy Redefined
3 Atopy of the Skin
4 Epidemiology
Section II: External Factors
5 Skin Barrier
6 Skin and Gut Microbiome
7 Immunogens
8 Nutrition
9 Oxidative Stress, Environmental factors, Pollutants
10 Clinical Evidence: External Factors
Section III: Internal Factors11 Keratinocytes
12 Microvasculature
13 Humoral Factors
14 Cellular Factors
15 Skin-Gut-Lung Epithelial Permeability
16 Neurosensory Mechanisms
17 Epigenetics
18 Clinical Evidence: Internal Factors
Section IV: Clinician's Corner19 Therapeutic Guideline Overview
20 Topical Therapies
21 Wound care
22 Skin barrier Repair
23 Emerging Targeted Treatments
24 Microbiome Modulation
25 Itch and Pain Treatments
26 Complementary and Alternative Approaches 1
27 Complementary and Alternative Approaches 2
About the author
Dr. Vivian Shi is the Director of Clinical Trials and the Eczema Specialty Clinic at the University of Arkansas for Medical Sciences. Her research and clinical interests are in complex inflammatory skin conditions, skin barrier repair, transepidermal drug delivery, and integrative dermatology. She was an integral part of the team of researchers characterizing the pathophysiology of atopic dermatitis using a transgenic interleukin-4 mouse model of atopic dermatitis. She has published over 150 peer-reviewed articles, and is on the speaker's bureau and the steering committee for the U.S. National Eczema Association and is a faculty member of the International Eczema Council. She has served as the principal investigator for numerous industry-sponsored and investigator-initiated clinical and translational studies in eczematous conditions. She regularly speaks in national and international conferences on atopic dermatitis and inflammatory skin conditions. Additionally, she is the recipient of the several prestigious awards and grants.
