Hydrogen Sulfide - Chemical Biology Basics, Detection Methods, Therapeutic

HYDROGEN SULFIDE
 
Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications
 
Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.
 
Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H2S in biological environments; and the therapeutic and medicinal uses of exogenous H2S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field.
* Provides approaches for delivering H2S with relevance to biological and therapeutic applications
* Describes complex interactions of H2S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species
* Summarizes advances in available tools to detect, measure, and modulate H2S levels in biological environments, such as real-time methods for H2S fluorescence imaging in live cell and animal systems
* Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action
* Includes in-depth case studies of different systems in which H2S plays an important role
 
Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.

List of contents

Preface xvii
 
List of Contributors xix
 
1 Fundamental and Biologically Relevant Chemistry of H2S and Related Species 1
Jon M. Fukuto
 
List of Abbreviations 1
 
1.1 Introduction 2
 
1.2 The Chemical Biology of H2S 2
 
1.2.1 Basic Chemical Properties of H2S 3
 
1.2.2 H2S Redox Chemistry 4
 
1.2.3 Reactions of H2S with Metals/Metalloproteins 5
 
1.2.4 H2S and Sulfheme Formation 6
 
1.2.5 H2S and Heavy Metals 7
 
1.3 H2S Reactions with Other Sulfur Species 8
 
1.3.1 Sulfane Sulfur 8
 
1.3.2 Generation of RSSH 8
 
1.3.3 RSH Versus RSSH Comparison 9
 
1.3.4 RSSH Interactions with Metals/Metalloproteins 14
 
1.3.5 The Electrophilicity of RSSH 14
 
1.3.6 Higher-Order Polysulfides 15
 
1.3.7 RSSH Instability 16
 
1.4 The Biochemical Utility of RSSH 17
 
1.5 Summary/Conclusion 18
 
References 18
 
2 Signaling by Hydrogen Sulfide (H2S) and Polysulfides (H2Sn) and the Interaction with Other Signaling Pathways 27
Hideo Kimura
 
List of Abbreviations 27
 
2.1 Introduction 28
 
2.2 Determination of the Endogenous Concentrations of H2S 29
 
2.3 H2S and H2Sn as Signaling Molecules 31
 
2.4 Crosstalk Between H2S and NO 32
 
2.4.1 The Chemical Interaction of H2S and NO Produces H2Sn 32
 
2.4.2 Regulation of NO-Producing Enzymes by H2S and Vice Versa 33
 
2.5 Cytoprotective Effect of H2S, H2Sn, and H2SO3 34
 
2.6 Energy Formation in Mitochondria with H2S 34
 
2.7 S-Sulfurated Proteins and Bound Sulfane Sulfur in Cells 35
 
2.8 Regulating the Activity of Target Proteins by H2S and H2Sn 36
 
2.8.1 S-Sulfuration by H2S 37
 
2.8.2 S-Sulfuration by H2Sn 38
 
2.9 Perspectives 38
 
Acknowledgments 40
 
Author Disclosure Statement 41
 
References 41
 
3 Persulfides and Their Reactions in Biological Contexts 49
Dayana Benchoam, Ernesto Cuevasanta, Matías N. Möller, and Beatriz Alvarez
 
List of Abbreviations 49
 
3.1 Persulfides Are Key Intermediates in Sulfur Metabolism and Signaling 49
 
3.2 Persulfides Are Formed in Biological Systems through Different Pathways 51
 
3.2.1 Disulfides Form Persulfides in the Presence of H2S 51
 
3.2.2 Sulfenic Acids Can Also Form Persulfides by Reaction with H2S 53
 
3.2.3 Other Persulfide Formation Pathways Involve Oxidation Products of H2S 53
 
3.2.4 Some Sulfur Atoms for Persulfides Are Donated by Free Cysteine 54
 
3.2.5 Trisulfides Are Also a Source of Persulfides 55
 
3.2.6 Persulfides Can Be Prepared in the Lab 56
 
3.3 Persulfides Are More Acidic Than Thiols 56
 
3.4 Persulfides Are Stronger Nucleophiles Than Thiols 58
 
3.5 Persulfidation Protects Against Irreversible Oxidation 60
 
3.6 Persulfides Interact with Metals and Metalloproteins 61
 
3.7 Persulfides Have Electrophilic Character in Both Sulfur Atoms 62
 
3.8 Persulfides Are Efficient One-Electron Reductants 63
 
3.9 Concluding Remarks 64
 
References 64
 
4 Hydrogen Sulfide, Reactive Nitrogen Species, and "The Joy of the Experimental Play" 77
Miriam M. Cortese-Krott
 
4.1 Introduction 77
 
4.2 Basic Physicochemical Properties of Nitric Oxide and Its Biological Relevant Metabolites 79
 
4.2.1 Nitric Oxide 79
 
4.2.2 Nitrite 80
 
4.2.3 Nitrosothiols (RSNOs) 81
 
4.3 Basic Physicochemical Properties of H2S and Its Biological Relevant Metabolites 82
 
4.3.1 H2S/HS. 83
 
4.3.2 Polysulfides and Persulfide 85
 
4.4 Inorgan

About the author

MICHAEL D. PLUTH, PhD is a Professor at the University of Oregon in the Department of Chemistry and Biochemistry. He is also a member of the Materials Science Institute, Knight Campus for Accelerating Scientific Impact, and Institute of Molecular Biology at the University of Oregon.

Summary

HYDROGEN SULFIDE

Covers H2S interactions, methods of detection and delivery in biological environments, and a wide range of applications

Research on hydrogen sulfide (H2S) spans diverse disciplines including chemistry, biology, and physiology. In recent years, new materials and approaches have been developed to deliver H2S and related reactive sulfur species in various clinical contexts. Although many biological pathways involving H2S are complex, all are governed by fundamental chemical interactions between reactive sulfur species and other molecular entities.

Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies provides the foundation required for understanding the fundamental chemical biology of H2S while highlighting the compound's therapeutic potential and medicinal applications. This book covers key aspects of H2S chemical biology, including the fundamental chemistry of reactive sulfur species; the measurement, detection, and delivery of H2S in biological environments; and the therapeutic and medicinal uses of exogenous H2S delivery in various pharmacologically relevant systems. Throughout the text, editor Michael Pluth and chapter contributors discuss the opportunities and future of the multidisciplinary field.
* Provides approaches for delivering H2S with relevance to biological and therapeutic applications
* Describes complex interactions of H2S with bioinorganic complexes and reactive sulfur, nitrogen, and oxygen species
* Summarizes advances in available tools to detect, measure, and modulate H2S levels in biological environments, such as real-time methods for H2S fluorescence imaging in live cell and animal systems
* Helps readers understand known systems and make connections to new and undiscovered pathways and mechanisms of action
* Includes in-depth case studies of different systems in which H2S plays an important role

Hydrogen Sulfide: Chemical Biology Basics, Detection Methods, Therapeutic Applications, and Case Studies is an important source of current knowledge for researchers, academics, graduate students, and industrial scientists in the fields of redox biology, hydrogen sulfide research, and medicinal chemistry of small biological molecules.

Product details

• Authors: Pluth, MD Pluth, Michael Pluth, Michael D Pluth, Michael D. Pluth, Binghe Wang
• Assisted by: Michael D Pluth (Editor), Michael Pluth (Editor), Michael D Pluth (Editor), Michael D. Pluth (Editor), Wang (Editor), Binghe Wang (Editor), Binghe Wang (Editor of the series), Wang Binghe (Editor of the series)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 28.02.2022
• EAN: 9781119799870
• ISBN: 978-1-119-79987-0
• No. of pages: 560
• Series: Wiley series in drug discovery and development; Wiley Drug Discovery and Devel
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Chemie, Life Sciences, Biowissenschaften, Chemische Biologie, chemistry, Zell- u. Molekularbiologie, Cell & Molecular Biology, Pharmaceutical & Medicinal Chemistry, Pharmazeutische u. Medizinische Chemie, Bioanorganische Chemie, Bioinorganic Chemistry, Schwefelwasserstoff