Stiff-Person Syndrome and Related Disorders - A Comprehensive, Practical Guide

This comprehensive title covers all of the broad aspects of stiff-person spectrum disorders (SPSD), ranging from clinical features and laboratory investigations to the basic scientific roles of neuroimmunology and genetics that aid clinicians in understanding the pathogenesis of this disorder.
Organized across 15 chapters, this highly practical book begins with a thorough account of the history and clinical phenomenology of SPSD.  Subsequent chapters then delve into the differential diagnoses of the disorder, as well as its electrophysiology, immunopathogenesis, and neurochemistry. Following this is an analysis of each subtype of SPSD including classic stiff-person syndrome and its variants, correlations between clinical phenotypes and antibodies, as well as SPSD in the pediatric population. Finally, the book concludes with an examination of the various SPSD diagnostic approaches, treatments, and potential emergencies seen in clinical practice.
Developed by a renowned multidisciplinary authorship, Stiff-Person Syndrome and Related Disorders is an indispensable contribution to the clinical literature and will be of great interest to both clinicians and basic science researchers.

List of contents

Historical background of stiff-person syndromes.- Clinical phenomenology and diagnostic criteria of stiff-person syndrome and stiff-person syndrome variants.- Differential diagnosis of stiff-person syndromes.- Electrophysiology of stiff-person syndromes.- Neurochemistry of inhibitory synapses and clinical applications in stiff-person syndromes.- Immunopathogenesis of stiff-person syndromes.- Antibodies in stiff-person syndrome and their correlations with clinical phenotypes.- Anti-glutamic acid decarboxylase 65 (GAD65)-associated syndromes.- Progressive encephalomyelitis with rigidity and myoclonus (PERM) syndrome.- Emergencies in stiff-person syndrome.- Diagnostic approach in stiff-person syndrome and its variants.- Treatment of stiff-person syndromes.- Pediatric stiff-person syndromes.- Peripheral hyperexcitability syndromes.- Hyperekplexia.

About the author

Pichet Termsarasab, MD

Faculty of Medicine Ramathibodi Hospital

Mahidol University

Bangkok, Thailand

 

Thananan Thammongkolchai, MD

Faculty of Medicine Ramathibodi Hospital

Mahidol University

Bangkok, Thailand

Bashar Katirji, MD

Academic affiliation: Professor of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. 

[e-mail]

Phone number: [phone]

Product details

Authors	Kati, Bashar Katirji, Piche Termsarasab, Pichet Termsarasab, Thanana Thammongkolchai, Thananan Thammongkolchai
Publisher	Springer, Berlin
Languages	English
Product format	Paperback / Softback
Released	11.06.2021
EAN	9783030430610
ISBN	978-3-0-3043061-0
No. of pages	183
Dimensions	155 mm x 9 mm x 235 mm
Illustrations	XV, 183 p. 46 illus., 20 illus. in color.
Subject	Natural sciences, medicine, IT, technology > Medicine > Clinical medicine

Product details

• Authors: Kati, Bashar Katirji, Piche Termsarasab, Pichet Termsarasab, Thanana Thammongkolchai, Thananan Thammongkolchai
• Publisher: Springer, Berlin
• Languages: English
• Product format: Paperback / Softback
• Released: 11.06.2021
• EAN: 9783030430610
• ISBN: 978-3-0-3043061-0
• No. of pages: 183
• Dimensions: 155 mm x 9 mm x 235 mm
• Illustrations: XV, 183 p. 46 illus., 20 illus. in color.
• Subject: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine