The Design of Covalent-Based Inhibitors

Annual Report on Medicinal Chemistry series, highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

List of contents

Preface
Richard Andrew Ward and Neil Grimster
1. The history of covalent inhibitors
Renato A. Bauer
2. Kinetic Mechanisms of Covalent Inhibition
Claire Louise McWhirter
3. Covalent Drugs in Development for Immune-Mediated Diseases
Leonard Sung
4. Chemistry Perspectives of Reversible Covalent Drugs
Jianmin Gao
5. Design of Next-Generation Covalent Inhibitors: Targeting Residues Beyond Cysteine
Lyn Jones
6. Boron and Covalent Inhibition
Andrew Leach
7. Measuring and predicting warhead and residue reactivity
Christopher Rowley
8. Computational Support of Structure-based Targeted Covalent Inhibitor Design
Robert Abel
9. Novel approaches to covalent inhibition
Nir London
10. The future of covalent inhibition
Gyorgy M. Keseru

About the author

Richard A. Ward is at AstraZeneca, UKNeil Grimster is at AstraZeneca, USA

Product details

• Assisted by: Neil Grimster (Editor), Richard A Ward (Editor)
• Publisher: Elsevier Science & Technology
• Languages: English
• Product format: Hardback
• Released: 30.09.2021
• EAN: 9780128216897
• ISBN: 978-0-12-821689-7
• Dimensions: 152 mm x 17 mm x 229 mm
• Weight: 610 g
• Series: Annual Reports in Medicinal Chemistry
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; SCIENCE / Chemistry / General, chemistry, Pharmacology