Haematology - From the Image to the Diagnosis

Haematology
 
Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis.
 
Using a novel format of visual case studies, this text mimics 'real life' for the practising diagnostic haematologist - using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work.
 
Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.

List of contents

Preface
 
Abbreviations
 
1. Haemophagocytic syndrome secondary to anaplastic large cell lymphoma
 
2. Bone marrow AL amyloidosis
 
3. Cup-like blast morphology in acute myeloid leukaemia
 
4. Neutrophil morphology
 
5. Primary myelofibrosis
 
6. Sarcoidosis
 
7. Leishmaniasis
 
8. Gelatinous transformation of the bone marrow
 
9. Acanthocytic red cell disorders
 
10. Large granular lymphocytic leukaemia
 
11. Pure erythroid leukaemia
 
12. Reactive mesothelial cells
 
13. Plasmablastic myeloma
 
14. Septicaemia
 
15. Unstable haemoglobin (haemoglobin Köln) and a myeloproliferative neoplasm
 
16. Sickle cell anaemia in crisis
 
17. Acute myeloid leukaemia with t(8;21)(q22;q22.1)
 
18. Chronic neutrophilic leukaemia
 
19. Essential thrombocythaemia
 
20. Hairy cell leukaemia
 
21. Mantle cell lymphoma in leukaemic phase
 
22. Infantile osteopetrosis
 
23. Reactive eosinophilia
 
24. Stomatocytic red cell disorders
 
25. Reactive lymphocytosis due to viral infection
 
26. Therapy-related acute myeloid leukaemia with eosinophilia
 
27. Red cell fragmentation syndromes
 
28. NK/T-cell lymphoma in leukaemic phase
 
29. Myelodysplastic syndrome with del(5q)
 
30. Classical Hodgkin lymphoma
 
31. Cryoglobulinaemia
 
32. Congenital dyserythropoietic anaemia
 
33. Acute monoblastic leukaemia with t(9;11)(p21.3;q23.3)
 
34. Chronic myeloid leukaemia presenting with myeloid sarcoma and extreme thrombocytosis
 
35. Glucose-6-phosphate dehydrogenase deficiency
 
36. Leukaemic presentation of hepatosplenic gamma-delta T-cell lymphoma
 
37. Myelodysplastic syndromes
 
38. Pelger-Huët anomaly
 
39. Russell bodies in lymphoplasmacytic lymphoma
 
40. T-cell prolymphocytic leukaemia
 
41. Myeloid maturation arrest
 
42. MDS/MPN with ring sideroblasts and thrombocytosis
 
43. Acute myeloid leukaemia with inv(16)(p13.1q22)
 
44. Babesiosis
 
45. Haemoglobin E disorders
 
46. Juvenile myelomonocytic leukaemia
 
47. Non-haemopoietic tumours
 
48. Richter transformation of chronic lymphocytic leukaemia
 
49. Sickle cell-haemoglobin C disease
 
50. T cell/histiocyte-rich B-cell lymphoma
 
51. Miliary tuberculosis
 
52. Pure red cell aplasia
 
53. Lymphoblastic transformation of follicular lymphoma
 
54. Primary hyperparathyroidism
 
55. Gamma heavy chain disease
 
56. Acute promyelocytic leukaemia with t(15;17)(q24.1;q21.2)
 
57. AA amyloidosis
 
58. Acquired sideroblastic anaemia
 
59. Diffuse large B-cell lymphoma
 
60. Hickman line infection
 
61. Monocytes and their precursors
 
62. Paroxysmal cold haemoglobinuria
 
63. Transient abnormal myelopoiesis
 
64. Systemic lupus erythematosus
 
65. Granular blast cells in acute lymphoblastic leukaemia
 
66. Chronic myelomonocytic leukaemia
 
67. Burkitt lymphoma/leukaemia
 
68. Gaucher's disease
 
69. Myelodysplastic syndrome with haemophagocytosis
 
70. Primary oxalosis
 
71. Acute myeloid leukaemia with inv(3)(q21.3q26.2)
 
72. Autoimmune haemolytic anaemia
 
73. Chronic eosinophilic leukaemia due to FIP1L1-PDGFRA fusion gene
 
74. Leukaemic phase of follicular lymphoma
 
75. Megaloblastic anaemia
 
76. Reactive bone marrow and an abnormal PET scan
 
77. Acute

About the author

About the Authors Mike Leach, MB ChB, FRCP, FRCPath, is Consultant Haematologist and Honorary Senior Lecturer at the Haematology Laboratories and West of Scotland Cancer Centre in Gartnavel General Hospital, Glasgow, UK. Barbara J. Bain, MB BS, FRACP, FRCPath, is Professor of Diagnostic Haematology at St Mary's Hospital Campus, Imperial College London, and Consultant Haematologist at St Mary's Hospital, London, UK.

Summary

Haematology

Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue ­fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis.

Using a novel format of visual case studies, this text mimics 'real life' for the practising diagnostic haematologist - using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work.

Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.

Report

The succinct description of the inset images are well synchronised with clear diction of the detailed clinical commentaries which facilitate integrated learning and reporting - the vital conduit that bridges the bench to the bedside. The whittling down of different diagnoses based on morphological features, along with the warnings about possible pitfalls in many cases, is a true bonus...This book is a 'must have' on the bookshelf of all clinicians and scientists who identify haematology as their calling and vocation.

Product details

• Authors: Barbara J Bain, Barbara J. Bain, M Leach, Mik Leach, Mike Leach, Mike (Gartnavel General Hospital Leach, Mike Bain Leach, Leach Mike
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 31.10.2021
• EAN: 9781119777502
• ISBN: 978-1-119-77750-2
• No. of pages: 304
• Subjects: Natural sciences, medicine, IT, technology > Medicine > General; Hämatologie, Medizin, Hematology, Medical Science