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This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.
Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.
List of contents
Prevalence, Needs, Strategies, and Risk Factors for Neurodegenerative Diseases. Activation of Microglia and Macrophages in Neurodegenerative Diseases.- Activation of Astrocytes in Neurodegenerative Diseases.- Tau Pathology in Neurodegenerative Diseases.- Role of SIRT3 and Mitochondrial Dysfunction in Neurodegeneration.- Oxidative Stress and Cellular Dysfunction in Neurodegeneratiove Disease.- Biomarkers in Parkinson's Disease.- Metabolomic Biomarkers in Parkinson's Disease.- Neuroinflammation in Huntington's Disease.- Biomarkers in Huntington Disease.- Biofluid Biomarkers of Amyotrophic Lateral Sclerosis.- MicroRNAs in Blood Serum, Blood Plasma, and Cerebrospinal Fluid as Diagnostic Biomarkers of Alzheimer's Disease.- Tau Biomarkers for Long-Term Effects of Neurotrauma: Technology Versus the Null Hypothesis.- Impedimetric Immunosensing for Neuroinflammatory Biomarker Profiling.- Aptamers Detection of Neurodegenerative Disease Biomarkers.- Possible Biomarkers for Frontotemporal Dementia and to Differentiate from Alzheimer's Disease and Amyotrophic Lateral Sclerosis.- TSPO PET Imaging as a Biomarker of Neuroinflammation in Neurodegenerative Disorders.- Validation of Diffusion Kurtosis Imaging as an Early Stage Biomarker of Parkinson's Disease in Animal Models.- Imaging Biomarkers in Huntington's Disease.- Imaging Biomarkers in Amyotrophic Lateral Sclerosis.- Trends in Biomarkers of Neurodegenerative Diseases.
