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Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine provides a comprehensive overview of mitochondrial dysfunction and current strategies for targeting the organelle. Based on the most current research, the editor lined up a team of worldwide experts to cover the most exciting research in the area, considering the impact through the human life span.
This book is structured in two parts that provide a good balance of foundational and applied content. Part I deals with an overview of mitochondrial dysfunction and its role in the aging process, including metabolic diseases, neuro-affective and neurodegenerative disorders, sepsis, and toxicological aspects. Part II covers therapeutic substance delivery to mitochondria with a focus on cancer, neurodegenerative diseases, and increasing the bioavailability of natural compounds of interest. Several nanoscale strategies are described.
Mitochondrial Dysfunction and Nanotherapeutics: Aging, Diseases, and Nanotechnology-Related Strategies in Mitochondrial Medicine is a complete resource for researchers in this exciting field. Its comprehensive coverage makes this book particularly interesting to bioscience researchers looking to understand the foundations of mitochondrial health throughout the human life span. Additionally, clinician researchers, medical doctors, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the organelle-targeted delivery strategies.
List of contents
Part I - Mitochondrial Dysfunction 1. Mitochondrial dysfunction and affective disorders: Focus on diet, exercise, and aging
2. Mitochondrial dysfunction in inborn errors of metabolism
3. Impaired mitochondrial dynamics in disease
4. Mitochondrial dysfunction in metabolic disorders
5. Mitochondrial dysfunction and autophagy in neurodegenerationin neurodegeneration
6. Mitochondrial dysfunction in sepsis
7. Drug or toxin induced mitochondrial toxicity
8. Aging, mitochondria, and autophagy
9. Skin aging and mitochondria
Part II - Strategies utilized to deliver natural molecules to the mitochondria 10. Organelle targeting: focus on the mitochondria
11. Nanotechnology, mitochondria, and cancer
12. Nanomaterials aimed towards the cardiac mitochondria: of therapeutics to nanosafety
13. Increasing resveratrol bioavailability: a therapeutic challenge focusing on the mitochondria
14. Advances in nanotechnology-related strategies against melanoma
15. Challenges in the delivery of polyphenols to cancer cells
16. Challenges in the nanoscale delivery systems development in the pharmaceutical and nutraceutical markets
17. Therapeutic implications of targeting antioxidants to the mitochondria
18. Nanomedicines and phytochemicals targeting Alzheimer's Disease
19. Mitochondria-targeted drugs and immune function
20. Polymeric Drug Delivery Systems for Mitigating Oxidative Stress
21. Polyphenols and the Microbiota: A Challenge in Mitochondrial Therapy
About the author
Marcos Roberto de Oliveira, PhD earned his bachelor’s degree in Biological Sciences at Federal University of Rio Grande do Sul (UFRGS) in 2005, followed by a master’s and a Ph.D. in Biochemistry from the same institution. He is currently a professor and coordinates research at UFRGS. His research focuses on the neuroprotection mediated by natural molecules and involves studies on mitochondrial physiology, redox biology, bioenergetics, and inflammation in both in vitro and in vivo experimental models.
