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List of contents
1. The Problem of Antigen-Receptor Heterogeneity and the Coherent Regulation of the Immune Response 2. Can a Mammalian Species with Monomorphic Class 1 MHC Molecules Succeed? 3. Immunological Quiescence Towards Self: Rethinking the Paradigm of Clonal Abortion 4. The One Receptor Model and T-Cells with High Affinity for Nonself Other Than Alloantigen 5. Suppressor T-Cells Are Not Easily Cloned by Methods for Clothing Helper T-Cells 6. Genetic Linkage of MHC and IGH-V-Linked Gene Products on T-Cell Regulatory Molecules 7. Anomalous Prolonged Allograft Survival after Deliberate Immunization against Graft-Specific Alloantigens 8. Tumor Dormancy as a Result of Simple Competition between Tumor Cells and Cytolytic Effector Cells 9. The Smell of H-2 10. Why Is the Immune System Not Overwhelmed by Suppression? A Reductionist Paradox 11. Are Rheumatoid Factors Produced during Conventional Immune Responses Beneficial to the Host? 12. T-Cell Regulation without Clonal Selection by Antigen? Polygamous Suppressor Cells and Monogamous Helper Cells at High Frequencies 13. Does Clonal Selection Apply to T-Cells? 14. B-Cells Can Be Activated in More Than One Way 15. T-Cell Proliferation and Differentiation 16. Idiotypic Networks in Tumor Immunity 17. The Paradox of Carbohydrate Histocompatibility Antigens 18. Paradoxes in B-Cell Stimulation by Polymeric Antigen and the Immunon Concept 19. Regulation of Idiotypic Profiles: Expected Dominance and Paradoxical Loss of T15 Expression 20. The Isogeneic Barrier Revisited: Cell Dose Effects and Loss of MHC Control of Responses 21. Paradoxical Primary Response of (P1 x P2) F1 Female Mice to Male P1 and P2 Skin 22. Idiotypes, Allotypes, and a Paradox of Inheritance 23. Are There Unique 1 Region-Controlled Determinants on T-Cells? 24. I-J – Immunoregulatory Molecules in Search of a Gene 25. Differences in the Recognition of MHC Class 1 Molecules by T-Cells and Antibodies
About the author
Geoffrey W. Hoffman is currently an Associate Professor in two departments at the University of British Columbia, namely, Physics and Microbiology.
Julia G. Levy is full Professor at the University of British Columbia in the Department of Microbiology.
Gerald T. Nepom is currently Director of the Division of Immunology at Virginia Mason Research Center in Seattle, Washington.
Summary
First published in 1986: Paradoxes play a key role in the advancement of science. They are associated with excitement, and with the knowledge that we must be looking at something the wrong way. This book discusses in detail Paradoxes in Immunology.
