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"Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. The book covers the history, trajectory of the research field, mechanisms of autophagy, and its regulation, developmental aspects, including stem cells, embryogenesis, hematopoiesis and paligenosis and focus on several systems, including Metabolic control and Diabetes, Cardiovascular, Nervous, Immune, Gastrointestinal, and Skeletal. The final chapters provide additional disease considerations, covering cancer, longevity, disease mechanisms, and the therapeutic targeting of autophagy. This book is invaluable to anyone looking for a broader understanding of autophagy outside their specific field"--
List of contents
Section I - Overview1. Introduction
Beverly A. Rothermel and Abhinav Diwan2. Mechanisms of autophagy: the machinery of macroautophagy and points of control
Congcong He
3. Regulation of autophagy - transcriptional, posttranscriptional, translational, and posttranslational mechanisms
Logan Slade and Thomas Pulinilkunnil4. Selectivity and trafficking of autophagic cargoes
Nuzhat Ahsan, Kautilya Kumar Jena, Subhash5. The role of lysosomes in autophagy
Yoana Rabanal-Ruiz and Viktor I. Korolchuk6. Methods for measuring autophagy
Allen Andres7. Effects of physiologic inputs on autophagy
Tobias Eisenberg, Mahmoud Abdellatif, Senka Ljubojevi¿-Holzer and Simon SedejSection II - Development8. Autophagy in germ cells, stem cells, and induced pluripotent stem cells
Moydul Islam, Ngoc Uyen Nhi Nguyen, Abhinav Diwan and Beverly A. Rothermel9. Role of autophagy in embryogenesis
Takayuki Tatsumi and Satoshi Tsukamoto
10. Autophagy in hematopoiesis and leukemogenesis
Angela Ianniciello and G. Vignir Helgason11. Autophagy in cell plasticity with particular focus on paligenosis
Megan D. Radyk, Lillian B. Spatz and Jason C. MillsSection III - Metabolic control and diabetes12. Autophagy in the liver
Mark Li and Ling Yang13. Autophagy in adipose tissue
Vishaka Vinod and Sihem Boudina14. Autophagy in the pancreas
Amelia Williams, Merilin Georgiou and Catherine Arden15. Skeletal muscle
Greg R. Markby and Kei SakamotoSection IV - Cardiovascular System16. Autophagy in the cardiovascular system
Daniel Peñ-Oyarzún, Valeria Garrido-Moreno, Luis Garrido-Olivares, Ramon Corbalan, Alfredo Criollo and Sergio Lavandero17. Lungs
Poornima Mahavadi, Martina Korfei and Andreas Guenther18. Autophagy in the vasculature
Bieke Steenput, Cédric HG. Neutel, Nina Hermans, Wim Martinet, Guido R.Y. De Meyer, Pieter-Jan Guns and Lynn RothSection V - The nervous system and neurodegeneration
19. Altered autophagy on the path to Parkinson's disease
Irene Sanchez-Mirasierra, Sergio Hernandez-Diaz, Saurav Ghimire, Patrick Main and Sandra-Fausia Soukup20. Autophagic processes in early- and late-onset Alzheimer's disease
Chenglong Xie, Yahyah Aman, Johannes Frank, Maria Jose Donate-Lagartos, Ruben Gudmundsrud, Kate¿ina ¿echová, Liu Shi, Martin Vyhnalek and Evandro F. FangSection VI - Homeostasis and disease in other organ systems21. Autophagy as an integral immune system component
Elizabeth Bueno, Samuel Wyatt, Robyn Duttenhefner, Daniel Asa, Srinivasulu Dasanna and Sangita C. Sinha22. Autophagy in the gastrointestinal system and cross talk with microbiota
Felipe X. Pimentel-Muiños23. Role of autophagy in building and maintaining the skeletal system
Olivier Camuzard, Marie-Charlotte Trojani, Georges F. Carle and Vale¿rie Pierrefite-Carle24. Autophagy on the road to longevity and aging
Maria Manifava and Nicholas T. Ktistakis25. Autophagy in cancer: friend or foe?
Silvia Vega-Rubín-de-Celis26. Mammalian microautophagy: mechanism and roles in disease
Takahiro Seki and Hiroshi Katsuki27. Chaperone-mediated autophagy - mechanisms and disease role
Amelina Albornoz, Alvaro Sequeida, Christian Rodríguez and Mauricio Budini28. Targeting autophagy: lifestyle and pharmacological approaches
Alfredo Briones-Herrera, Tania Gómez-Sierra, Elena Martínez-Klimova, Belén Bellido and José Pedraza-Chaverr
About the author
Bev Rothermel, PhD, is an Associate Professor at the University of Texas Southwestern Medical Center in Dallas, TX, with appointments in the Departments of Internal Medicine (Cardiology) and Molecular Biology. Her laboratory was directly involved in some of the first studies demonstrating the dual nature of autophagy in the cardiovascular system. She has lectured on the role of autophagy in human disease for more than ten years as a component of the graduate school’s Integrative Biology program. Current studies in her lab seek to understand circadian regulation of cardiac mitophagy as well as identify the causes and consequences of suppressed autophagy in Down syndrome. Her research is supported by the National Institutes of Health’s INCLUDE Project, the Wellstone Muscular Dystrophy Research Network, and the American Heart Association.Abhinav Diwan, MBBS, is a physician-scientist and a board-certified cardiologist, and directs a laboratory-based research program focused on basic and translational studies to therapeutically target the autophagy-lysosome pathway in human disease. He is Professor of Medicine, Cell Biology and Physiology, and Obstetrics and Gynecology at Washington University in Saint Louis, Missouri, USA and Staff Physician at the John Cochran Veterans Affairs Medical Center in Saint Louis. Studies from his laboratory have uncovered evidence for acquired lysosome dysfunction as a common cellular in cardiomyopathy and heart failure, Alzheimer’s disease and diabetes. Translational research from his program has established the autophagy-lysosome pathway as a viable therapeutic target, with activation of the lysosome biogenesis program as an exciting strategy in these conditions. He has also proven to be an outstanding mentor to the next generation of physician-scientists, an effort he leads as the program director of the Investigator Training Pathway in the Cardiovascular Division supported by a NIH T32 training grant.
