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This issue of Neurosurgery Clinics, guest edited by Drs. Guy McKhann and Hugues Duffau, with consulting editors Russell R. Lonser and Daniel K. Resnick, will focus on Low-Grade Glioma. Topics includes, but are not limited to, Epidemiology and Molecular Epidemiology; WHO Pathological and Molecular Classification; Molecular Pathogenesis; Glioma Cell Migration and Heterogeneity; Clinical Presentation, Natural History, and Prognosis; LGG Epilepsy; MRI, fMRI, DTI, Molecular Imaging; Brain Mapping Techniques in LGG; Surgical Adjuncts to Increase EOR iMRI, Flourescence, Raman Histology; Mapping Cognition and Emotion; Extent of Resection; EOR vs Molecular Classification; Chemotherapy Treatment and Trials; Radiotherapy Treatment and Trials; Higher Order Surgical Questions; and Building a Glioma Practice.
List of contents
1. Epidemiology and Molecular Epidemiology 2. Molecular Pathogenesis 3. Alterations in the Brain Microenvironment in Diffusely Infiltrating Low Grade Glioma 4. Clinical Presentation, Natural History and Prognosis of Diffuse Low-Grade Gliomas 5. LGG Epilepsy 6. Mapping in Low Grade Glioma Surgery: Low and High Frequency Stimulation 7. Surgical Adjuncts to Increase EOR iMRI, Fluorescence, Raman Histology 8. Beyond Language: Mapping Cognition and Emotion 9. Evidence for Improving Outcome through Extent of Resection 10. EOR Versus Molecular Classification: What Matters When? 11. Chemotherapy Treatment and Trials in Low Grade Gliomas 12. Low-Grade Glioma Radiotherapy Treatment and Trials 13. Higher Order Surgical Questions for Diffuse Low-Grade Gliomas: Supramaximal Resection, Neuroplasticity and Screening 14. Building a Glioma Practice
About the author
Dr. McKhann is Professor of Neurological Surgery at Columbia University Irving Medical Center/New York Presbyterian Hospital, where he is Director of Epilepsy Surgery and co-Director of the Division of Neuro-Oncology. He has over 25 years of experience at CUIMC/NYP, combining clinical skill and compassionate care to maximize patient outcomes. He is a member of both the Columbia P&S Virginia Apgar Academy of Medical Educators and the P&S Academy of Clinical Excellence. His areas of particular technical expertise include epilepsy surgery; awake and asleep brain mapping; brain tumor surgery, in particular low and high grade glioma and brain metastasis surgery; and stereotactic laser ablation for epilepsy and tumors. Dr. McKhann also works as a translational neuroscientist, directing the Epilepsy Neurophysiology Laboratory.
