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Provides perspective, covers recent developments in technologies that have enabled the expanded use of biomarkers, discusses biomarker characterization and validation, and applications throughout the discovery-development continuum, including Companion Diagnostic ( CDX) development.
List of contents
Introduction. What is a Biomarker and its Role in Drug Development? Biomarkers in Discovery and PreClinical Safety. Translating From Pre-Clinical Results to Clinical and Back. Biomarkers in Clinical Trials -Design Considerations for Biomarker Informed Clinical Trials. The road ahead: Identification of the hurdles and solutions to the implementation of personalized medicine in healthcare. Lessons from the past and pioneers of the future. Paving a new era of personalized medicine: Emerging technologies. The next frontiers of therapeutic target areas: Autoimmunity, inflammation, respiratory, metabolic, cardiovascular and neurological diseases. Lessons Learned: What have we learned and what is the next challenge?
About the author
Claudio Carini, Mark Fidock, Alain van Gool
Summary
Provides perspective, covers recent developments in technologies that have enabled the expanded use of biomarkers, discusses biomarker characterization and validation, and applications throughout the discovery-development continuum, including Companion Diagnostic ( CDX) development.
Additional text
"This handbook is hardcover and was published at CRC Press / Taylor and Francis Group in 2019. From the first time I opened it, I could notice that the printing and quality of paper is exceptional. The handbook has 631 pages and very nicely coloured figures, schemes and drawings, that are very easily understandable and very helpful in processing the text of the handbook. The field of biomarkers is approached in this book in a scholastic manner, starting from the first discovery and use of biomarkers to the regulatory approaches in the field of precision medicine, passing from preclinical studies, translational medicine, clinical trials, and implementation in practice. Several case-studies are presented related to HIV diagnosis, infertility, coagulation, BRCA identification, but also case-studies related to biomarker-based clinical trials... This handbook is complete, exact, succinct and unique, and gathers information from different perspectives, useful to different players from the field of biomarkers in precision medicine, making it a an excellent tool for learning. First of all, I would recommend this handbook to researchers from the medical and connected fields. It could help the development of this engaging field of personalized care due to highly accurate and relevant data presented by the authors. Secondly, I would recommend it to medical doctors from all specialties since it offers a deep and comprehensive approach into a field that only a few decades ago was hardly recognized and since the practice of medicine in most specialties during the following years will, for sure, include a personalized approach to
patients. Both these addressees, researchers and medical practitioners, can make a difference. Least but not last, I would say that even residents and medical students would benefit from the comprehensive approach that this book provides."
- Costela Serban, ISCB December 2019
