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This volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.
List of contents
Preface.- Hemodynamics and vascular remodeling.- The biomechanics of venous remodeling.- New kids on the block: the emerging role of YAP/TAZ in vascular cell mechano-transduction.- GPCRs und flow and pressure.- Biomechanics in small artery remodeling.- Contributions of wall stretch and shear stress to vascular regulation: Molecular mechanisms of homeostasis and expansion.- Mechanobiology of lymphatic vessels.- Hemodynamic control of endothelial cell fates in development.- Mechanical regulation of epigenetic modifications in vascular biology and pathobiology.- Mechanosensing and mechanotransduction in pulmonary hypertension.- Mechanobiology of arterial hypertension.- Mechanobiology of atherosclerosis.- Exploitation of vascular mechanobiology for cardiovascular therapy.
About the author
Prof. Markus Hecker is Managing Director of the Institute of Physiology and Pathophysiology, Heidelberg University, Germany.Prof. Dirk Jan Duncker, PhD, MD is an established PI in the field of cardiovascular research and heart failure and head of the department of experimental cardiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands.
Report
"The quality of this book is excellent. It is a valuable resource for cardiologists, internists, physicians in training, and mid-level providers." (Michelle Waters, Doody's Book Reviews, November 05, 2021)
