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This book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery.
Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide.
List of contents
1.Cell Wall Biosynthesis and Latency During Tuberculosis Infections.- 2. The Silent Plague: Regulation of Latent Tuberculosis Infections.- 3. Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis.- 4. Role of Myeloid-derived Suppressor Cells and Regulatory T-cells in the Tuberculous Granuloma.- 5. Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells.- 6. Role of Mycobacterium tuberculosis PE and PPE proteins in pathogen-host interactions.- 7. Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy.- 8. Optical In Vivo Imaging in Tuberculosis Research.- 9. Mycobacteria Infection and Lipid Droplets - Host and Pathogen Stealing, Sharing and Storing Fat.- 10. Potential Immunology, Transcriptomics and Epigenomic Prediction Tools of the Future to Improve Tuberculosis Control.
About the author
Dr. Jeffrey D. Cirillo is a Regents¿ Professor at Texas A&M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis.
Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.
Report
"This is a compendium of reviews covering the basics of tuberculosis pathogenesis and the interaction with the human host. ... This will be useful to seasoned researchers who want a review of the field and to learn about recent advances." (Carlos E Figueroa Castro, Doody's Book Reviews, January 31, 2020)
