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This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development.
* Highlights nearly three hundred medicines on the latest World Health Organization (WHO) Model List of Essential Medicines and their manufacturing routes
* Features exercises that equip students with the skills necessary to solve similar real-world problems
* Includes a retrosynthetic analysis for each commodity chemical and supplies an extensive list of key journal and information sites and a library of reagents, solvents, and conditions for many common organic reactions
List of contents
Introduction xiv
About the Companion Website xvii
A 1
Abacavir 1
Acetazolamide 3
Acetylcysteine 4
Acetylsalicylic Acid 4
Acyclovir 5
Albendazole 6
Allopurinol 7
Amidotriazoate 8
Amikacin 9
Amiloride 11
4-Aminosalicylic Acid 12
Amiodarone 13
Amitriptyline 15
Amlodipine 16
Amodiaquine 17
Amoxicillin 18
Ampicillin 20
Anastrozole 21
Artemether 23
Artesunate 24
Ascorbic Acid 26
Atazanavir 27
Atracurium Besylate 29
Atropine 32
Azathioprine 34
Azithromycin 35
Aztreonam 37
B 40
Beclomethasone Dipropionate 40
Bedaquiline 45
Bendamustine 47
Benznidazole 49
Benzoyl Peroxide 50
Benzyl Benzoate 51
Betamethasone 52
Bicalutamide 56
Biperiden 57
Bisoprolol 58
Budesonide 59
Bupivacaine 62
C 63
Caffeine 63
Calcium Folinate/Folinic Acid 64
Capecitabine 65
Carbamazepine 67
Cefalexin 68
Cefazolin 69
Cefepime 71
Cefixime 73
Cefotaxime 75
Ceftaroline 77
Ceftazidime 81
Ceftriaxone 84
Chlorambucil 86
Chloramphenicol 87
Chlorhexidine 89
Chloroquine 90
Chloroxylenol 91
Chlorpromazine 92
Ciprofloxacin 93
Cisplatin, Carboplatin, Oxaliplatin 94
Clarithromycin 97
Clindamycin 99
Clofazimine 100
Clomifene 101
Clomipramine 102
Clopidogrel 103
Cloxacillin 105
Clotrimazole 106
Clozapine 107
Codeine 108
Colecalciferol 109
Cyclizine 112
Cyclophosphamide 113
Cycloserine 114
Cytarabine 114
D 116
Dacarbazine 116
Daclatasvir 117
Dapsone 119
Darunavir 120
Dasabuvir 122
Dasatinib 124
Delamanid 126
Desmopressin 129
Dexamethasone 131
Diazepam 136
Diethylcarbamazine 137
Dihydroartemisinin 139
Diloxanide Furoate 140
Dimercaprol 141
Docetaxel 141
Docusate Sodium 145
Dolutegravir 145
Dopamine 147
Doxycycline 148
E 150
Efavirenz 150
Eflornithine 152
Emtricitabine 153
Enalapril 155
Entecavir 158
Ephedrine 160
Epinephrine 160
Ergocalciferol 162
Ergometrine 163
Estradiol Cypionate 164
Ethambutol 166
Ethinylestradiol 166
Ethionamide 167
Ethosuximide 169
Etonogestrel 169
Etoposide 173
F 175
Fentanyl 175
Fluconazole 176
Flucytosine 177
Fludarabine Phosphate 177
Fludrocortisone Acetate 179
Fluorouracil 180
Fluoxetine 181
Fluphenazine 182
Folic Acid 184
Fomepizole 185
Formoterol 186
Fosfomycin 189
Furosemide 191
G 192
Gemcitabine 192
Gliclazide 194
Glutaral 195
Glyceryl Trinitrate 196
H 197
Haloperidol 197
Halothane 199
Hydra
About the author
Peter J. Harrington, PhD, is the owner and primary consultant for Better Pharma Processes LLC, Boulder, Colorado, USA. Dr. Harrington is a pharmaceutical process design and development expert with more than twenty years' experience in timely process innovation for major pharmaceuticals. His publications include a book on pharmaceutical process chemistry for synthesis and several articles on organic and medicinal chemistry.
Summary
This comprehensive workbook helps readers become familiar with the structures and synthetic challenges associated with nearly 300 essential medicines and gain the skills needed for pharmaceutical development.
* Highlights nearly three hundred medicines on the latest World Health Organization (WHO) Model List of Essential Medicines and their manufacturing routes
* Features exercises that equip students with the skills necessary to solve similar real-world problems
* Includes a retrosynthetic analysis for each commodity chemical and supplies an extensive list of key journal and information sites and a library of reagents, solvents, and conditions for many common organic reactions
