Computational Modeling and Simulation Examples in Bioengineering

A systematic overview of the quickly developing field of bioengineering--with state-of-the-art modeling software!
 
Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering.
 
The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering:
* Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book
* Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods
* Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more
* Explores stent deployment modeling as well as stent design and optimization techniques
* Generates different examples of fracture fixation with respect to the advantages in medical practice applications
 
Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.

List of contents

Editor Biography xi
 
Author Biographies xii
 
Preface xv
 
1 Computational Modeling of Abdominal Aortic Aneurysms 1
Nenad D. Filipovic
 
1.1 Background 1
 
1.2 Clinical Trials for AAA 2
 
1.3 Computational Methods Applied for AAA 3
 
1.4 Experimental Testing to Determine Material Properties 6
 
1.5 Material Properties of the Aorta Wall 8
 
1.6 ILT Modeling 9
 
1.7 Finite Element Procedure and Fluid-Structure Interaction 12
 
1.7.1 Displacement Force Calculations 12
 
1.7.2 Shear Stress Calculation 13
 
1.7.3 Modeling the Deformation of Blood Vessels 13
 
1.7.4 FSI Interaction 15
 
1.8 Data Mining and Future Clinical Decision Support System 16
 
1.9 Conclusions 19
 
References 23
 
2 Modeling the Motion of Rigid and Deformable Objects in Fluid Flow 33
Tijana Djukic and Nenad D. Filipovic
 
2.1 Introduction 33
 
2.2 Numerical Model 35
 
2.2.1 Modeling Blood Flow 36
 
2.2.2 Modeling Solid-Fluid Interaction 40
 
2.2.2.1 Modeling the Motion of Rigid Particle 42
 
2.2.2.2 Modeling the Motion of Deformable Particle 45
 
2.2.3 Modeling Deformation of the Particle 46
 
2.2.3.1 Force Caused by the Surface Strain of Membrane 47
 
2.2.3.2 Force Caused by the Bending of the Membrane 51
 
2.2.3.3 Force Caused by the Change of Surface area of the Membrane 51
 
2.2.3.4 Force Caused by the Change of Volume 52
 
2.2.4 Modeling the Flow of Two Fluids with Different Viscosity that are Separated by the Membrane of the Solid 52
 
2.3 Results 54
 
2.3.1 Modeling the Behavior of Particles in Poiseuille Flow 55
 
2.3.2 Modeling the Behavior of Particles in Shear Flow 57
 
2.3.3 Modeling Behavior of Particles in Stenotic Artery 74
 
2.3.4 Modeling Behavior of Particles in Artery with Bifurcation 77
 
2.4 Conclusion 81
 
References 82
 
3 Application of Computational Methods in Dentistry 87
Ksenija Zelic Mihajlovic, Arso M. Vukicevic, and Nenad D. Filipovic
 
3.1 Introduction 87
 
3.2 Finite Element Method in Dental Research 88
 
3.2.1 Development of FEM in Dental Research 89
 
3.2.1.1 Morphology and Dimensions of the Structures - Application of Digital Imaging Systems 90
 
3.2.1.2 FE Model - Required/Composing Structures 91
 
3.2.1.3 Simulating Occlusal Load 92
 
3.2.1.4 Boundary Conditions 94
 
3.2.1.5 Importance of Periodontal Ligament, Spongious, and Cortical Bone 95
 
3.2.2 Overview of FEM in Dental Research - Most Important Topics in the Period 2010-2020 96
 
3.2.2.1 FEM in the Research Related to Implants, Restorative Dentistry, and Prosthodontics 97
 
3.2.2.2 FEM in Analysis of Biomechanical Behavior of Structures in Masticatory Complex 101
 
3.2.2.3 FEM in Orthodontic Research 102
 
3.2.2.4 FEM in Studies of Trauma in the Dentoalveolar Region 103
 
3.3 Examples of FEA in Clinical Research in Dentistry 103
 
3.3.1 Example 1- Assessment of Critical Breaking Force and Failure Index 104
 
3.3.1.1 Background 104
 
3.3.1.2 Materials and Methods 104
 
3.3.1.3 Results and Discussion 111
 
3.3.2 Example 2 - Assessment of the Dentine Fatigue Failure 118
 
3.3.2.1 Background 118
 
3.3.2.2 Materials and Methods 119
 
3.3.2.3 Results and Discussion 124
 
References 131
 
4 Determining Young's Modulus of Elasticity of Cortical Bone from CT Scans 141
Aleksandra Vulovic and Nenad D. Filipovic
 
4.1 Introduction 141
 
4.2 Bone Structure 143
 
4.3

About the author

NENAD D. FILIPOVIC, PhD, is a Professor in the Faculty of Engineering and Head of the Center for Bioengineering at the University of Kragujevac, Serbia. He also leads national and international projects in bioengineering and software development, including joint research projects with Harvard University and the University of Texas. He is a Managing Editor for the Journal of the Serbian Society for Computational Mechanics and a member of IEEE, European Society of Biomechanics (ESB).

Summary

A systematic overview of the quickly developing field of bioengineering--with state-of-the-art modeling software!

Computational Modeling and Simulation Examples in Bioengineering provides a comprehensive introduction to the emerging field of bioengineering. It provides the theoretical background necessary to simulating pathological conditions in the bones, muscles, cardiovascular tissue, and cancers, as well as lung and vertigo disease. The methodological approaches used for simulations include the finite element, dissipative particle dynamics, and lattice Boltzman. The text includes access to a state-of-the-art software package for simulating the theoretical problems. In this way, the book enhances the reader's learning capabilities in the field of biomedical engineering.

The aim of this book is to provide concrete examples of applied modeling in biomedical engineering. Examples in a wide range of areas equip the reader with a foundation of knowledge regarding which problems can be modeled with which numerical methods. With more practical examples and more online software support than any competing text, this book organizes the field of computational bioengineering into an accessible and thorough introduction. Computational Modeling and Simulation Examples in Bioengineering:
* Includes a state-of-the-art software package enabling readers to engage in hands-on modeling of the examples in the book
* Provides a background on continuum and discrete modeling, along with equations and derivations for three key numerical methods
* Considers examples in the modeling of bones, skeletal muscles, cartilage, tissue engineering, blood flow, plaque, and more
* Explores stent deployment modeling as well as stent design and optimization techniques
* Generates different examples of fracture fixation with respect to the advantages in medical practice applications

Computational Modeling and Simulation Examples in Bioengineering is an excellent textbook for students of bioengineering, as well as a support for basic and clinical research. Medical doctors and other clinical professionals will also benefit from this resource and guide to the latest modeling techniques.

Product details

• Authors: N Filipovic, Nenad Filipovic
• Assisted by: Nena Filipovic (Editor), Nenad Filipovic (Editor), Filipovic Nenad (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Hardback
• Released: 31.08.2021
• EAN: 9781119563945
• ISBN: 978-1-119-56394-5
• No. of pages: 384
• Series: IEEE Press Series on Biomedical Engineering; IEEE Press Biomedical Engineer
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Biomedizinische Technik, bioengineering, Materialwissenschaften, Materials science, Biomedical engineering, Biomedizintechnik, Materialwissenschaften / Theorie, Modellierung u. Simulation, Theory, Modeling & Simulation, Allg. Biomedizintechnik, Rechnergestütztes Bioengineering, Computational Bioengineering