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Zusatztext "...the book successfully achieves its goal of presenting the basic principles and challenges associated with the discovery and scale-up of a commercial manufacturing process of a new drug." - Journal of Medicinal Chemistry "...gives a thorough overview of the challenges facing the modern development chemists in the pharmaceutical industry. It can be recommended to any graduates or postgraduates considering a career in this fascinating field! and even old hands will find much stimulating chemistry in the case studies. " - Organic Process Research & Development "...provides a good overview for those wanting an introduction to the science conducted in a process research group. For experienced process chemists! frequent descriptions of creative solutions to difficult problems makes the book worth reading." - Journal of the American Chemical Society "...recommended without reservation. It is suitable not only for the process chemist but also for those involved in preparative work in research in teaching! and for advanced students. It should find a place in every chemical library." - Angewandte Chemie "...presents pharmaceutical synthesis at its best in a very concise and educational way. The wealth of references and illustrations! and the carefully compiled subject index guarantees fast access to further information....the lively style in which chapters are written keeps the reader interested along the way." - European Journal of Pharmaceutics and Biopharmaceutics! 2000 Informationen zum Autor Kumar Gadamasetti Klappentext Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchersa "offering a solid grounding in synthetic "and" physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, "Process Chemistry in the Pharmaceutical Industry" is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines. Zusammenfassung Offers a basis in synthetic and physical organic chemistry. This guide highlights strategies for aggressive drug development programs, green synthesis processes, and other trends in the industry. It illustrates the impact of non-traditional small molecules as a therapeutic agent, including case studies on agents such as inhibitors and antagonists. Inhaltsverzeichnis Overview Process Chemistry in the Pharmaceutical Industry: An Overview , Kumar G. Gadamasetti Strategy Process Research and Development Strategy for Accelerated Projects , Christopher M. Cimarusti Case Studies A Practical Synthesis of Ifetroban Sodium , Richard H. Mueller Synthesis of 5-Lipoxygenase Inhibitors , Ivan Lantos and Richard Matsuoka Chemistry of Vitamin D: A Challenging Field for Process Research , Masami Okabe A Highly Optimized and Concise Large Scale Synthesis of a Purine Bronchodilator , Hans-Jürgen Federsel and Edib Jakupovic Ontazolast: The Evolution of a Process , Vittorio Farina, Karl Grozinger, Hermann Müller-Bötticher and Gregory P. Roth Dilevalol Hydrochloride: Development of a Commercial Process , Derek Walker Design and Development of Practical Syntheses of LY228729, a Potent 5HT1a Receptor Agonist , Michael J. Martinelli and David L. Varie Process Research and Development of CGS 19755, an NMDA Antagonist , Peter Giannousis, John Carlson and Marius Leimer Route Evaluation for the Production of (R)-Levoprotiline , H. U. Blaser, R. Gamb...
