Nanoparticles Induce Oxidative and Endoplasmic Reticulum Stresses - Antioxidant Therapeutic Defenses

This book provides insights and tools for better understanding redox biology and medicine and, in the long run, to finding new therapeutic strategies to target dysregulated redox processes in various diseases. It presents the recent advances in new nanomedication technologies of the effects of nanoparticles NPs on oxidative stress, RONS and ER stress. The book comprises 13 chapters covering ecotoxicology, cytotoxicity, nanotoxicity and genotoxicity mechanisms causing by the role and interactions of nanoparticles and free radicals with (RONS) and (ER) stress. Endoplasmic Reticulum (ER) Stress as a mechanism for NPs induced toxicity has been discussed. The advances of nanotechnology and the effects of nanoparticles on oxidative stress, ROS and ER stress parameters are discussed. Antioxidants, therapeutic options and regulation of the immune responses are explained throughout the book.

List of contents

Ecotoxicology of Environmental Heavy Metal Ions and Free Radicals on Macromolecules Cells Organisms.- Nanotoxicity, Cytotoxicity and Genotoxicity Mechanisms of Nanomaterials.- Sources of Oxidants and Function of (ROS) inside the Macromolecules Cells.- The Roles and Mechanisms of ROS, Oxidative Stress and Oxidative Damage.- Consequences of Oxidative Stress and ROS-Mediated Pathways Cellular Signaling Stress Response.- Interactions between Heavy Metals-Induced Cell Responses and Oxidative Stress.- Pathways for Nanoparticles NPs- Induced Oxidative Stress.- Role of Endoplasmic Reticulum ER Stress-Induced Cell Death Mechanisms.- Endoplasmic Reticulum (ER) Stress as a Mechanism for NP Induced Toxicity.- Advances Nanotechnology and Effects of Nanoparticles on Oxidative Stress Parameters.- Improvement Testing Strategy for Aligning Nanomaterial Safety Assessments and Oxidative Stress Responses.- Antioxidant Therapeutic Defenses towards Redox Biology and Oxidative Stress.- Antioxidants, Therapeutic Options and Regulation of the Immune Responses.

About the author

Prof. LOUTFY H. MADKOUR: (Egyptian) has been a Professor of Physical Chemistry, Nano Science and Nanotechnology at Chemistry Department, Faculty of Science and Arts, Al Baha University, Baljarashi, 65635, Saudi Arabia (KSA), since 2012 till now.

He received his B.Sc., M.Sc. and Ph.D. from the Cairo, Minia and Tanta Universities of the AR Egypt, respectively in Physical Chemistry. He worked as a lecturer chemistry at the Tanta University since 1982 and as a professor of physical chemistry in 1999. He has conducted a series of studies in the field of physical chemistry in the field of electrochemistry, corrosion science, density functional theory, molecular dynamic simulation, quantum, theoretical chemistry, chemical equalization principles, nanoscience, nanotechnology, Nano medicine; electrometallurgy, electroanalytical chemistry, analytical chemistry, polarography, electrolytic extraction of heavy metals from natural ores and deposits, electrochemical thermodynamics and environmental chemistry. His earlier research accomplishments include Biosynthesis of Metallic Nanoparticles (MNPs)s and toxicology studies for Pharmacological applications in medicine and therapy. He has published 150 peer-reviewed original research articles, 11 review articles, and 6 books in the area of physical chemistry, practical and applied chemistry, corrosion science, Nanoscience and Nano medicine. He is serving in different positions in Egypt, Kuwait, Yemen, and Saudi Arabia.

Prof. MADKOUR is appointed as the prestigious Editorial Board member of several international journals such as: International Journal of Industrial Chemistry (IJIC) Published by the SPRINGER; International Journal of Ground Sediment & Water; E-Cronicon Chemistry (EC Chemistry); BAOJ Chemistry; Global Drugs and Therapeutics (GDT); Chronicles of Pharmaceutical Science (ISSN 2572-7761) journal; Journal of Targeted Drug Delivery. UNIQUE PUB INTERNATIONAL UPI Journal of Pharmaceutical, Medical and Health Sciences; and Global Journal of Nanomedicine (GJN) ISSN: 2573-2374; Research and Reviews in Computational Chemistry Journal and Journal of Pharmaceutical sciences-current research (JPSCR) in the area of Pharmaceutical, Pharmacology, Journal of Pharmacology & Pharmaceutical Research (JPPR); Archives of Pharmacy & Pharmacology Research journal- APPR and Drug Designing & Development (NAPDD) website; the Pharmaceutical Sciences & Analytical Research Journal (PSARJ); Nanotechnology & Applications (NTA); the Clinical Pharmacology and Toxicology Research; The Laboratory Medicine Journal; Journal Drug Design Development & Therapy MEDCRAVEONLINE.COM MOJDDT; Journal of Pharmacy and Drug Development. E Scientific Publishers and ADVANCES AND APPLICATIONS OF PHARMACY Journal published online by MDPI quarterly. He has joined as an Editorial Board member in Journal of Clinical and Medical Research; International Journal of Environmental Chemistry, Science PG Publishing Group and LOJ Pharmacology & Clinical Research (LOJPCR). He has been uploaded as the Editorial Board member in CPQ MEDICINE (CPQME) Journal and Japan Journal of Research. He has been uploaded as the Editorial Board member in Organic & Medicinal Chemistry International Journal (OMCIJ).

Product details

• Authors: Loutfy H Madkour, Loutfy H. Madkour
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.04.2020
• EAN: 9783030372965
• ISBN: 978-3-0-3037296-5
• No. of pages: 696
• Dimensions: 161 mm x 237 mm x 48 mm
• Weight: 1266 g
• Illustrations: 29 SW-Abb., 139 Farbabb.
• Series: Nanomedicine and Nanotoxicology
• Subject: Natural sciences, medicine, IT, technology > Technology > Miscellaneous