Computer Techniques in Preclinical and Clinical Drug Development

It is estimated that 80 to 90% of drugs under development never make it to the marketplace due to a number of factors that should be, at least partially, predictable from preclinical testing. Computer Techniques in Preclinical and Clinical Drug Development asks the question, "How can we use computational methods to improve the success rate in drug development?" It shows how modeling makes it possible to extract the maximum amount of information and predictive value from preclinical data. Computer modeling methods from the areas of pharmacokinetics, pharmacodynamics, cytokinetics, and inhibition kinetics of multi-enzyme pathways are all discussed in this unique reference source.

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List of contents

Introduction: The Preclinical and Clinical Drug Development Process Physiological Pharmacokinetic Modeling Interspecies Scaling Prediction of Drug Metabolism and Toxicity Pharmacodynamic Modeling Cytokinetic Modeling Prediction of Drug Resistance Conclusions: The Virtual Clinical Trial References Appendix: Computational Pharmacology Software Suppliers Abbreviations Index

About the author

Jackson, Robert C.

Product details

• Authors: Robert C Jackson, Robert C. Jackson, Jackson Robert C.
• Publisher: Taylor & Francis Ltd.
• Languages: English
• Product format: Paperback / Softback
• Released: 31.12.2019
• EAN: 9780367401283
• ISBN: 978-0-367-40128-3
• No. of pages: 256
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; MEDICAL / Laboratory Medicine, Medical laboratory testing & techniques, Medical laboratory testing and techniques