Good Research Practice in Non-Clinical Pharmacology and Biomedicine

This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.

List of contents

1. Quality in Non-GxP Research Environment.- 2. Guidelines & Initiatives for Good Research Practice.- 3. Learning from principles of evidence-based medicine to optimize nonclinical research practices.- 4. General Principles of Preclinical Study Design.- 5. Resolving the tension between exploration and confirmation in preclinical biomedical research.- 6. Blinding and Randomization.- 7. Out of control?  Managing baseline variability in experimental studies with control groups.- 8. Quality of Research Tools.- 9. Genetic background and sex: impact on generalizability of research findings in pharmacology studies.- 10. Building robustness intro translational research.- 11. Minimum information and quality standards for conducting, reporting, and organizing in vitro research.- 12. Minimum Information in In Vivo Research.- 13. A reckless guide to P-values: Local evidence, global errors.- 14. Electronic Lab Notebooks and Experimental Design Assistants.- 15. Data storage.- 16. Design of meta-analysis studies.- 17. Publishers' responsibilities in promoting data quality and reproducibility.- 18. Quality governance in biomedical research.- 19. Good Research Practice - Lessons from Animal Care & Use.- 20. Research collaborations and quality in research: foes or friends?.- 21. Costs of implementing quality in research practice.

Product details

• Assisted by: Anton Bespalov (Editor), Marti C Michel (Editor), Martin C Michel (Editor), Martin C. Michel (Editor), Thomas Steckler (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2020
• EAN: 9783030336554
• ISBN: 978-3-0-3033655-4
• No. of pages: 423
• Dimensions: 157 mm x 29 mm x 241 mm
• Weight: 798 g
• Illustrations: X, 423 p. 34 illus., 21 illus. in color.
• Series: Handbook of Experimental Pharmacology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Neurowissenschaften, Pharmakologie, Kardiologie, Angiologie, reproducibility; Studydesign; dataanalysis; datareporting; DataIntegrity; qualitymanagement; OpenAccess