Gram-Positive Pathogens

Gram-positive bacteria, lacking an outer membrane and related secretory systems and having a thick peptidoglycan, have developed novel approaches to pathogenesis by acquiring (among others) a unique family of surface proteins, toxins, enzymes, and prophages. For the new edition, the editors have enhanced this fully researched compendium of Gram-positive bacterial pathogens by including new data generated using genomic sequencing as well as the latest knowledge on Gram-positive structure and mechanisms of antibiotic resistance and theories on the mechanisms of Gram-positive bacterial pathogenicity. This edition emphasizes streptococci, staphylococci, listeria, and spore-forming pathogens, with chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically, in an attempt to understand the strategies used by these bacteria to cause human disease.
 

"This textbook comprises a superb collection of scientific knowledge making it a must-read for any graduate student, medical doctor, or investigator studying these gram-positive bacteria and inspiring future imaginations of biological knowledge." - William R. Jacobs, Jr., PhD, Professor Microbiology & Immunology, Albert Einstein College of Medicine

List of contents

Dedication
 
Contributors
 
Preface About the Editors
 
Section 1: The Gram-Positive Cell Wall
Vincent A. Fischetti
 
1 The Gram-Positive Cell Wall
Manfred Rohde
2 Surface Proteins on Gram-Positive Bacteria
Vincent A. Fischetti
Section 2: The Streptococcus
Vincent A. Fischetti and Joseph J. Ferretti
 
Group A Streptococci
3 Intracellular Invasion by Streptococcus pyogenes: Invasins, Host Receptors, and Relevance to Human Disease
Beinan Wang and P. Patrick Cleary
4 Capsular Polysaccharide of Group A Streptococci
Michael Wessels
5 Toxins and Superantigens of Group A Streptococci
Blake A. Shannon, John K. McCormick, and Patrick M. Schlievert
6 Genetics of Group A Streptococci
Kyu Hong Cho, Gary Port, and Michael Caparon
7 Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and Their Sequelae
Madeline W. Cunningham
8 Extracellular Matrix Interactions with Gram-Positive Pathogens
Sven Hammerschmidt, Manfred Rohde, and Klaus T. Preissner
9 Streptococcus-Mediated Host Cell Signaling
Vijay Pancholi
10 Vaccine Approaches to Protect Against Group A Streptococcal Pharyngitis
Vincent Fischetti
11 The Bacteriophages of Group A Streptococci
W. Michael McShan
12 Molecular Epidemiology, Ecology, and Evolution of Group A Streptococci
Debra E. Bessen, Pierre R. Smeesters, and Bernard W. Beall
Group B Streptococci
13 Surface Structures of Group B Streptococci Important to Human Immunity
Lawrence Paoletti and Dennis Kasper
14 Epidemiology of Group B Streptococcal Infections
Vanessa N. Raabe and Andi L. Shane
Group C and G Streptococci
15 Genetics and Pathogenicity Factors of Group C and G Streptococci
Horst Malke
16 Pathogenicity Factors in Group C and G Streptococci
Claire E. Turner, Laura Bubba, and Androulla Efstratiou
17 Infections Caused by Group C and G Streptococcus (Streptococcus dysgalactiae subsp. equisimilis and Others): Epidemiological and Clinical Aspects
Gio Baracco
 
Streptococcus pneumoniae
18 The Cell Wall of Streptococcus pneumoniae
Waldemar Vollmer, Orietta Massidda, and Alexander Tomasz
19 Streptococcus pneumoniae Capsular Polysaccharide
James Paton and Judy Morona
20 Streptococcus pneumoniae: Invasion and Inflammation
Allister J. Loughran, Carlos J. Orihuela, and Elaine I. Tuomanen
21 Phase Variation of Streptococcus pneumoniae
Jing Li and Jing-Ren Zhang
22 Genetics of Streptococcus pneumoniae
Francesco Santoro, Francesco Iannelli, and Gianni Pozzi
23 Pneumococcal Vaccines
David E. Briles, James C. Paton, Reshmi Mukerji, Edward Swiatlo, and Marilyn J. Crain
Enterococci
24 Pathogenicity of Enterococci
Elizabeth M. Selleck, Daria Van Tyne, and Michael S. Gilmore
25 Enterococcal Genetics
Keith E. Weaver
Oral Streptococci
26 Biology of Oral Streptococci
J. Abranches, L. Zeng, J. K. Kajfasz, S. R. Palmer, B. Chakraborty, Z. T. Wen, V. P. Richards, L. J. Brady, and J. A. Lemos
27 The Biology of Streptococcus mutans
J. A. Lemos
 
28 Genetics of Sanguinis-Group Streptococci in Health and Disease
Angela Nobbs and Jens Kreth
Lactococci
29 Genetics of Lactococci
Philippe Gaudu, Yuji Yamamoto, Peter Ruhdal Jensen, Karin Hammer, Delphine Lechardeur, and Alexandra Gruss
Section 3: The Staphylococcus
Richard P. Novick
 
30 The Evolving Genome
Jodi Lindsay
 
31 Plasmids and Transposable and Integrative Elements
Neville Firth, Slade O. Jensen, Stephen M. Kwong, Ronald A. Skurray, and Joshua P. Ramsay
32 Temperate Phages of Staphylococcus aureus
Hanne Ingmer, David Gerlach, and Christine Wolz
33 Pathogenicity Islands and Their Role in Staphylococcal Biology
Richard Novick
34 Respiration and Small Colony Variants of Staphylococcus aureus
Richard Proctor
35 Noncoding RNA
Emma D

Summary

Gram-positive bacteria, lacking an outer membrane and related secretory systems and having a thick peptidoglycan, have developed novel approaches to pathogenesis by acquiring (among others) a unique family of surface proteins, toxins, enzymes, and prophages. For the new edition, the editors have enhanced this fully researched compendium of Gram-positive bacterial pathogens by including new data generated using genomic sequencing as well as the latest knowledge on Gram-positive structure and mechanisms of antibiotic resistance and theories on the mechanisms of Gram-positive bacterial pathogenicity. This edition emphasizes streptococci, staphylococci, listeria, and spore-forming pathogens, with chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically, in an attempt to understand the strategies used by these bacteria to cause human disease.

"This textbook comprises a superb collection of scientific knowledge making it a must-read for any graduate student, medical doctor, or investigator studying these gram-positive bacteria and inspiring future imaginations of biological knowledge." - William R. Jacobs, Jr., PhD, Professor Microbiology & Immunology, Albert Einstein College of Medicine

Report

"This textbook comprises a superb collection of scientific knowledge making it a must-read for any graduate student, medical doctor, or investigator studying these gram-positive bacteria and inspiring future imaginations of biological knowledge."
 
- William R. Jacobs, Jr., PhD
Professor Microbiology & Immunology, Albert Einstein College of Medicine

Product details

• Authors: Mirian Braunstein, Joseph J. Ferretti, FISCHETTI, VA Fischetti, Vincent A. Fischetti, Richard P. Novick, Daniel A. Portnoy, Julian I. Rood
• Assisted by: Mirian Braunstein (Editor), Joseph J. Ferretti (Editor), Vincent A. Fischetti (Editor), Joseph J Ferretti et al (Editor), Richard P. Novick (Editor), Richar P Novick (Editor), Richard P Novick (Editor), Daniel A. Portnoy (Editor), Julian I. Rood (Editor)
• Publisher: Wiley & Sons
• Languages: English
• Product format: Hardback
• Released: 31.01.2020
• EAN: 9781683670124
• ISBN: 978-1-68367-012-4
• Series: ASM Books; ASM
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Clinical medicine; Mikrobiologie, Medizin, microbiology, PATHOGENE, Medical Science, Mikrobiologie u. Virologie, Grampositive Pathogene