Cancer Chemotherapy - Basic Science to the Clinic

Provides a clear and accessible summary of all stages and aspects of the discovery, design, development, validation and clinical use of anticancer drugs
 
This new edition provides an update on the current state of the art of cancer chemotherapy and clinical practice and presents new pipeline anticancer agents and promising therapeutic strategies that are emerging alongside new breakthroughs in cancer biology. Its unique approach enables students to gain an understanding of the pathological, physiological, and molecular processes governing malignancy, while also introducing the role of health professionals and scientists in the research and treatment of cancer.
 
Invaluable for its clarity and accessibility, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition offers complete coverage of the scientific and clinical aspects of the creation, development, and administration of drugs or drug regimens used in the treatment of the disease. Chapters look at: cancer epidemiology and histopathology; carcinogenesis; current research; tumor hypoxia; antiangiogenic and antivascular agents; protein kinase and Ras blockers; new targets associated with development such as Hedgehog and Wnt signaling; stem cells; immunotherapy and oncolytic viruses; and more.
* Presents a clear, accessible, and comprehensive approach to cancer chemotherapy from basic science to clinical practice
* Offers a major update that reflects the latest developments in personalized chemotherapy
* Provides in-depth coverage of advances in biomarker diagnostics
* Includes new chapters/sections on bioinformatics and the 'omic sciences'; pharmaceutical strategies used to achieve tumor-selective drug delivery; and cancer cell autophagy
* Combines descriptions of both clinical protocol and explanations of the drug design process in one self-contained book
* Features numerous diagrams and illustrations to enhance reader understanding
 
Aimed at upper undergraduate, graduate, and medical students, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition is also an excellent reference for health professional, especially clinicians specializing in Clinical Oncology, and their patients who want to gain an understanding of cancer and available treatment options.

List of contents

Preface xi
 
About the Companion Website xiii
 
1 Cancer Epidemiology 1
 
1.1 Cancer Incidence and Mortality 1
 
1.2 Childhood Cancer 4
 
1.3 Global Epidemiology 5
 
1.4 Cancer Survival Rates 8
 
1.5 Summary and Conclusions 12
 
Further Reading 12
 
2 Cancer Histopathology 13
 
2.1 Cancer Morphology, Phenotype, and Nomenclature 14
 
2.2 Apoptosis 16
 
2.3 Necrosis 22
 
2.4 Autophagy and Others 23
 
2.5 Summary and Conclusions 24
 
Further Reading 25
 
3 Carcinogenesis 27
 
3.1 Initiation 27
 
3.2 Promotion 29
 
3.3 Progression and Environmental Carcinogenesis 30
 
3.4 Cell Cycle 31
 
3.5 Summary and Conclusions 33
 
Further Reading 33
 
4 Molecular Biology of Cancer 35
 
4.1 Oncogenes: Disruptors and Instigators 36
 
4.2 Cellular Oncogenes 39
 
4.3 Viral Oncogenes 41
 
4.4 Altered Oncogenic Products 42
 
4.5 Biological Carcinogens 44
 
4.6 Tumor Suppressor Genes 46
 
4.7 Familial Cancers and Cancer Syndromes 50
 
4.8 Summary and Conclusions 52
 
Further Reading 52
 
5 Cancer Metastasis 53
 
5.1 Detachment from the Primary Tumor 54
 
5.2 Migration of Cancer Cells from Primary Tumor 55
 
5.3 Intravasation of Tumor Cells into Vessels 57
 
5.4 Metastatic Transport 60
 
5.5 Extravasation 61
 
5.6 Growth of the Metastatic Tumor Mass 63
 
5.6.1 Cancer Dormancy 63
 
5.6.2 Extracellular Matrix of the Tumor Microenvironment 64
 
5.6.3 Seed and Soil 65
 
5.7 Summary and Conclusions 66
 
Further Reading 67
 
6 Health Professionals and Cancer Treatment 69
 
6.1 Pathology 69
 
6.2 Radiology 70
 
6.3 Biopsies 72
 
6.4 Surgical Treatment 73
 
6.5 Oncology Pharmacy 74
 
6.6 Oncology Nursing 75
 
6.7 Artificial Intelligence and Healthcare 75
 
6.8 Summary and Conclusions 75
 
Further Reading 76
 
7 Principles of Cancer Chemotherapy 77
 
7.1 Staging, Treatment, and Monitoring 77
 
7.2 General Types of Chemotherapy 79
 
7.3 Biomarker Uses and Limitations 82
 
7.4 Pharmacogenetics, Pharmacogenomics, Pharmacokinetics, Pharmacodynamics, and Personalized Medicine 86
 
7.5 Summary and Conclusions 87
 
Further Reading 88
 
8 Cytotoxic Compounds 89
 
8.1 Alkylating Agents 89
 
8.2 Intercalating Agents 94
 
8.3 Topoisomerase Blockers 104
 
8.4 Tubulin Disruptors 109
 
8.5 Summary and Conclusions 113
 
Further Reading 113
 
9 Antimetabolites and Hormonal Blockers 115
 
9.1 Nucleic Acid Analogs 115
 
9.2 Folate Analogs 118
 
9.3 Amino Acid Blockers 120
 
9.4 Hormone Modulators 121
 
9.5 Estrogen Antagonists 124
 
9.6 Aromatase Inhibitors 127
 
9.7 Antiandrogens 127
 
9.8 Endocrine Therapy 128
 
9.9 Summary and Conclusions 129
 
Further Reading 130
 
10 Cancer Research 131
 
10.1 Gel Electrophoresis Methods 131
 
10.2 Polymerase Chain Reaction 132
 
10.3 Molecular Cloning 133
 
10.4 Enzyme-Linked Immunosorbent Assay, Immunohistochemistry, and Immunofluorescence 134
 
10.5 Mass Spectroscopy and Proteomics 135
 
10.6 Genomics, Transcriptomics, and Metabolomics 136
 
10.7 Microarrays 137
 
10.8 Cell Culture and Exogenous Expression Strategies 138
 
10.9 Protein Expression and Targeting 141
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About the author

GARY S. GOLDBERG, PhD, is an Associate Professor at the School of Osteopathic Medicine, Rowan University, Stratford, NJ, USA.

RACHEL AIRLEY, MRes, PhD, MRPharmS, FHEA, is a Community Pharmacist and former Lecturer in Pharmacology and Cancer Sciences, Manchester, UK.

Summary

Provides a clear and accessible summary of all stages and aspects of the discovery, design, development, validation and clinical use of anticancer drugs

This new edition provides an update on the current state of the art of cancer chemotherapy and clinical practice and presents new pipeline anticancer agents and promising therapeutic strategies that are emerging alongside new breakthroughs in cancer biology. Its unique approach enables students to gain an understanding of the pathological, physiological, and molecular processes governing malignancy, while also introducing the role of health professionals and scientists in the research and treatment of cancer.

Invaluable for its clarity and accessibility, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition offers complete coverage of the scientific and clinical aspects of the creation, development, and administration of drugs or drug regimens used in the treatment of the disease. Chapters look at: cancer epidemiology and histopathology; carcinogenesis; current research; tumor hypoxia; antiangiogenic and antivascular agents; protein kinase and Ras blockers; new targets associated with development such as Hedgehog and Wnt signaling; stem cells; immunotherapy and oncolytic viruses; and more.
* Presents a clear, accessible, and comprehensive approach to cancer chemotherapy from basic science to clinical practice
* Offers a major update that reflects the latest developments in personalized chemotherapy
* Provides in-depth coverage of advances in biomarker diagnostics
* Includes new chapters/sections on bioinformatics and the 'omic sciences'; pharmaceutical strategies used to achieve tumor-selective drug delivery; and cancer cell autophagy
* Combines descriptions of both clinical protocol and explanations of the drug design process in one self-contained book
* Features numerous diagrams and illustrations to enhance reader understanding

Aimed at upper undergraduate, graduate, and medical students, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition is also an excellent reference for health professional, especially clinicians specializing in Clinical Oncology, and their patients who want to gain an understanding of cancer and available treatment options.

Product details

• Authors: Rachel Airley, Rachel (Liverpool John Moores University U Airley, Gary Goldberg, Gary S Goldberg, Gary S Airley Goldberg, Gary S. Goldberg, Gary S. (Rowan University Goldberg, Gary S. Airley Goldberg, Gs Goldberg
• Assisted by: Airley (Editor), Airley (Editor), Rachel Airley (Editor), Airley Rachel (Editor), Gary S. Goldberg (Editor), Gar S Goldberg (Editor), Gary S Goldberg (Editor)
• Publisher: Wiley, John and Sons Ltd
• Languages: English
• Product format: Paperback / Softback
• Released: 29.02.2020
• EAN: 9781118963852
• ISBN: 978-1-118-96385-2
• No. of pages: 320
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Non-clinical medicine; Chemie, Medizin, Onkologie, Chemotherapie, Pharmakologie, chemistry, Pharmacology & Pharmaceutical Medicine, Pharmakologie u. Pharmazeutische Medizin, Medical Science, Pharmaceutical & Medicinal Chemistry, Pharmazeutische u. Medizinische Chemie, Medizinische Onkologie, Medical Oncology