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Informationen zum Autor Cynthia A. Challener currently works as a freelance writer and information management consultant to the chemical industry. She has had experience in research and development! technical support! regulatory compliance! marketing and document and information management. Cynthia received her BS in Chemistry in 1986 from Stanford University and her PhD in Organic Chemistry in 1990 from the University of Chicago. Klappentext In the early twentieth century the relevance of chirality to thepharmaceutical industry was established by the fact that oneenantiomer of hyoscyamine possessed greater pharmacologicalactivity than the other. Today! most new drugs and those underdevelopment consist of a single optically active isomer! andchirality is also becoming an issue for the agrochemical and otherindustries. Regulatory agencies throughout the world are currentlyreviewing the importance of chirality with regard to pharmaceuticaland agrochemical products. New guidelines from such agencies havebeen key drivers for the focus on single enantiomer products inthese industries.These scientific and regulatory developments have created the needfor a guide for workers in the pharmaceutical and chemicalindustries seeking information on chiral molecules! processes! andcommercially available chiral chemicals. Chiral Intermediatespresents the chemical professional with a comprehensive listing ofover 4700 available chiral chemicals including specific data ofinterest for each entry in the listing. Its companion volume!Chiral Drugs presents the same detailed information for over 2000chiral drugs.The 'Chiral Pool' of readily available! relatively inexpensivechiral compounds has been expanding at a rapid rate as more andmore products are produced in large quantities at economicalprices. New developments in various technologies for isolating!preparing! and purifying chiral materials have greatly increasedthe opportunities for utilizing optically pure compounds incommercial applications. Novel techniques for classical resolution!new methodologies for developing selective enzymes forbiocatalysis! advances in the application of microorganisms forchemical production! and continued progress in the area ofasymmetric synthesis have all contributed to the growth of thisfield.Part I contains four chapters which provide an introduction totopics relevant to the field of chiral chemistry and includes abrief overview of chirality! a short discussion on the currentmarket drivers in the area of chiral chemistry! and a basicpresentation of the various sources and methods for obtainingchiral compounds.Part II presents entries for 4700 commercially available chiralcompounds. For each main entry! the chemical name and a list oftrade names and synonyms is provided; the CAS Registry Number! theEuropean Inventory of Existing Commercial Chemical Substances(EINECS) number! and the Merck Index (12th edition) number aregiven when available. The physical properties! including specificrotation! of each compound are described and indicated applicationsare presented. The structure of nearly every compound is provided!and the manufacturers and suppliers of the compounds are alsogiven. Indexes! including a master index of names and synonyms andan index of custom manufacturing services for production of chiralcompounds! are appended.Chiral Intermediates provides an introduction to the types ofsources and methods currently in use for obtaining chiral moleculesand is an invaluable resource for information on available chiralmolecules. Chiral Intermediates and Chiral Drugs are the mostcomprehensive and detailed guides to chiral compounds available. Zusammenfassung Regulatory agencies throughout the world are reviewing the importance of chirality with regard to pharmaceutical and agrochemical products. Guidelines from such agencies have been key drivers for the focus on single enantiomer products in these industries.<...
