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The ever-shortening timelines and the high costs of drug discovery and development have brought about the need for high throughput approaches to methods that are currently used in the pharmaceutical industry. Written by well-known contributors, this book systematically describes high-throughput analysis for the industry. Exploring advanced instrumentation and automated sample preparation, the text discusses various techniques, including HPLC, MALDI-MS, and LC-MS/MS methods. An emphasis is placed on the later stage of drug development and the book includes discussions of topics such as pharmacokinetics.
List of contents
High-Throughput Sample Preparation Techniques and Their Application to Bioanalytical Protocols and Purification of Combinatorial Libraries. On-line Sample Extraction Coupled with Muliplexing Strategy to Improve Throughput. Optimizing LC/MS Equipment to Increase Throughput in Pharmaceutical Analysis. Throughput Improvement of Bioanalytical LC/MS/MS by Sharing Detector between HPLC Systems. High-Throughput Strategies for Metabolite Identification in Drug Discovery. Utilizing Microparallel Liquid Chromatography for High-Throughput Analyses in the Pharmaceutical Industry. Strategies and Techniques for Higher Throughput ADME/PK Assays. High-Throughput Analysis in Drug Metabolism During Early Drug Discovery. High-Throughput Analysis in Support of Process Chemistry and Formulation Research and Development in the Pharmaceutical Industry. Online Solid Phase Extraction LC/MS/MS for High-Throughput Bioanalytical Analysis. Applications of High-Throughput Analysis in Therapeutic Drug Monitoring. High-Throughput Quantitative Pharmaceutical Analysis in Drug Metabolism and Pharmacokinetics Using Liquid Chromatography–Mass Spectrometry. Designing High-Throughput HPLC Assays for Small and Biological Molecules. Advances in Capillary and Nano HPLC Technology for Drug Discovery and Development. High-Throughput Analysis of Complex Protein Mixtures by Mass Spectrometry. Index
About the author
Perry G. Wang
