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This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants. Chapters guide readers through the application of color tests, light microscopy-based particle imaging, GC-MS, Raman spectroscopy, capillary electrophoresis, ultra-high performance LC-tandem MS, DART-MS, MALDI-mass spectrometry imaging, LC-MS/MS and HPLC-ESI-MS/MS to the analysis of abused drugs in wastewater, hair, urine and plant-derived materials, among other matrices. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Analysis of Drugs of Abuse aims to ensuresuccessful results in the further study of this vital field.
List of contents
Color Tests for the Preliminary Identification of New Psychoactive Substances.- Illicit and Counterfeit Drug Analysis by Morphologically Directed Raman Spectroscopy.- Analysis of Drugs of Abuse by Gas Chromatography-Mass Spectrometry (GC-MS).- Towards Confirmatory On-site Real-Time Detection of Emerging Drugs Using Portable Ultrafast Capillary Electrophoresis Mass Spectrometry.- Use of DART-TOF for Screening Drugs of Abuse.- Confirmation of Pharmaceutical Identifiers via DART-TOF.- UPLC-Orbitrap® Screening for Over 35 Drugs of Abuse and Metabolites in Biological Fluids Under 10 Minutes.- Sensitivity Enhancement in Capillary Electrophoresis Using Magnetic Particles as Solid-phase Extraction Sorbents for the Determination of Drugs of Abuse in Urine.- High Throughput Extraction and Detection of Drugs in Urine: Parallel Sampling with Solid-Phase Microextraction (SPME) Fibers Coupled with Direct Analysis in Real Time - Mass Spectrometry (DART-MS) Detection.- Analysis of Drugs of Abusein Hair Samples by Ultra High Performance Liquid Chromatography/Tandem Mass Spectrometry (UHPLC-MS/MS).- Comprehensive Drug Screening by Thermal Desorption and Pyrolysis Combined with Direct Analysis in Real Time-Mass Spectrometry (TDP/DART-MS).- Detection of Diagnostic Plant-derived Psychoactive Biomarkers in Fingerprints by MALDI-SpiralTOF-MS.- Matrix-assisted Laser Desorption Ionization Imaging Mass Spectrometry of Drug Distributions in Mouse Brain Tissue by High-resolution Time-of-flight Mass sSectrometry.- Estimation of Community Usage of Drugs Utilizing Sewage.- LC-MS-MS Method Development and Analysis of Stimulants, Opiates, Synthetic Opiates, PCP, and Benzodiazepines in Wastewater. Preponderance of these Drugs During Football Games.- Analysis of Illicit Drugs in Wastewater Using High Performance Liquid Chromatography - Electrospray Ionization - Tandem Mass Spectrometry (HPLC-ESI-MS/MS).- Analysis of Trace Drugs of Abuse by Direct Analysis in Real Time (DART) Mass Spectrometry.- A Rapid, High-throughput Validated Method for the Quantification of Atropine in Datura stramonium Seeds Using Direct Analysis in Real Time-high Resolution Mass Spectrometry (DART-HRMS).- Utilizing Direct Analysis in Real Time-high Resolution Mass Spectrometry-derived Dark Matter Spectra to Classify and Identify Unknown Synthetic Cathinones.
Summary
This volume features a comprehensive set of protocols featuring a range of both old and new technologies that can be used to analyze drugs of abuse, including prescription drugs, new psychoactive substances and psychoactive plants.
