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This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases.
By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.
List of contents
Brain Iron Metabolism and CNS Diseases.- Cellular iron metabolism and regulation.- Brain iron metabolism and regulation.- Iron pathophysiology in Parkinson diseases.- Iron pathophysiology in Alzheimer's diseases.- Iron pathophysiology in stroke.- Iron pathophysiology in Friedreich's ataxia.- Iron pathophysiology in amyotrophic lateral sclerosis.- Iron pathophysiology in Neurodegenerative with Brain Iron Accumulation.- Diagnostics and treatments of iron-related CNS diseases
About the author
Dr. Yan-Zhong Chang is a Professor, the Director of the Department of Physiology, and Dean of the College of Life Sciences, Hebei Normal University. He is a member of the Biophysical Society of China (BSC) committee, and the Associate Director of the Free Radical Biology and Biological Trace Element Branches of BSC, as well as of the Neuroendocrine and Metabolic Branch of the Chinese Society for Neuroscience (CSN). He also served as a member of the advisory board of Cellular and Molecular Life Sciences and of the editorial board of the Journal of Biochemical and Pharmacological Research. Prof. Chang’s research focuses on iron metabolism and related diseases, and he has published more than 100 articles in this field.
Summary
This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases.
By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.
