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List of contents
1. Pyrrolo [2,3-d] Pyrimidine Nucleosides 2. Purine Nucleoside Phosphorylase: A Target for Chemotherapy 3. The Interaction of Methotrexate and 5-Fluoracil 4. Inhibition of Cytidine Deaminase: Mechanism and Effects on the Metabolism of Antitumor Agents 5. Metabolic and Mechanistic Studies with Tiazofurin (β-D-Ribofuranosylthiazole-4-Carboxamide) 6. Antimitotic Drugs and Tubulin-Nucleotide Interactions 7. Cellular and Molecular Pharmacology of Sugar Amine-Modified Anthracyclines 8. Intercalator-Induced Protein-Associated DNA Strand Breaks in Mammalian Cells 9. Growth Inhibitory Effects of Interferons and (2’,5’) Oligoadenylate and its Analogs 10. The 2’,5’-Oligoadenylates and Their Analogs: Biochemical Probes in the Treatment of Cancer and Virus-Related Diseases 11. Induction of Differentiation of the Human Promyelocytic Cell Line HL-60 and Primary Cultures of Human Leukema Cells: A Model for Clinical Treatment
About the author
Robert I. Glazer, Ph.D., Chief, Applied Pharmacology Section, Laboratory of Medicinal Chemistry and Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Summary
First published in 1984: The broad scope of this book was intentionally designed as such to emphasize the enormous complexity, as well as the number of biological processes which can be exploited to derive new approaches for the treatment of cancer.
