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The proposed book aims to understand the mechanism of survival of microorganisms in response to chemical stress in various ecological niches that suffer direct human intervention, more so the agricultural, domestic and hospital settings. Microbicides (e.g. disinfectants, antiseptics, fungicides, algaecides, insecticides and pesticides) are used rampantly to control undesirable microbes. Insecticides and pesticides are routinely used in agriculture which directly affect the microbial population in farms, orchards and fields. Health care environments are always stressed with disinfectants and antibiotics. It is always probable that microbicide-stressed microorganisms are in a dynamic state, displaced from one niche to the other. Some soil and water borne bacteria or their resistance determinants are also getting prominence in hospital settings after suffering selective pressure from agricides. In order to reveal the survival strategies of microbicidal-resistant microbes, it isof prime importance to know the mode of action of these complete range of microbicides (agricides to antibiotics). The present book intends to address these issues. There will be several chapters dealing with tolerance and cross resistance in microbes and bacteria in particular, dwelling in various niches. Till date, there is no consensus among scientists in theorizing molecular mechanisms to explain bacterial tolerance and their cross resistance to agricides and antibiotics.
List of contents
Chapter 1. Plasmids: The necessary Knowledge Wealth for Encountering Antibiotic-Resistance menace.- Chapter 2. Disinfectants amend the expression of membrane bound efflux transporters to augment antimicrobial resistance.- Chapter 3. Knowledge gaps and research needs in bacterial co-resistance in the environment.- Chapter 4. Microbial resistance to Antibiotics.- Chapter 5. Do non-medical uses of antibiotics develop cross-resistance in clinical pathogens?.- Chapter 6. Biofilms in antimicrobial activity and drug resistance.- Chapter 7. GAntimicrobial resistance in microbes: Mode of action of TolC like protein and their mechanism of regulating stress resistance and physiology.- Chapter 8. Efflux mediated co-resistance.- Chapter 9. Biofilm and Antibiotic resistance in Acinetobacter baumannii.- Chapter 10. Mechanism of bacterial co-resistance.- Chapter 11. Antibiotics and Microbial Antibiotic Resistance in Soil.- Chapter 12. Microbial adaptation and resistance to pesticides.- Chapter 13. Antimicrobial agents used in food preservation or as agricides and effect on microbes in developing antimicrobial resistance.- Chapter 14. Molecular Mechanisms of Action and Resistance of Antimalarial drugs.- Chapter 15. Management and control of antimalarial drug resistance.
About the author
Santi M. Mandal obtained his Ph D in the field of Molecular Microbiology and continuing research with major focus in Antimicrobial Chemotherapy. He visited UTMB-USA and NUS-Singapore for his postdoctoral training. He worked as an Assistant Professor of Microbiology at Vidyasagar University, India. He has published more than 110 research papers in reputed journals and conferred upon several prestigious awards for his research contribution. Currently, he is engaged at Central Research Facility, Indian Institute of Technology Kharagpur, Kharagpur India.
Debarati Paul (PhD) currently Associate Professor in The Department of Biotechnology, Amity University, has completed her PhD from the Institute of Microbial Technology-CSIR (Chandigarh) and thereafter she carried our research work abroad in EAWAG (Switzerland) and Mississippi State University (USA) for about 5 years, before joining Amity University, Uttar Pradesh, NOIDA as Assistant Professor.Her main area of research is environmental biotechnology, encompassing biodegradation, biofuels, genomics and proteomics and also antimicrobial resistance. She has published over 70 papers including research articles, reviews, conference proceedings and posters and book chapters. She has actively participated in national and international projects as research fellow and also as principal investigator (PI) as co-PI. She has received the prestigious Indo US Science and Technology forum award and Bharat Gaurav award along with DST travel grants, poster award, etc.
Summary
The proposed book aims to understand the mechanism of survival of microorganisms in response to chemical stress in various ecological niches that suffer direct human intervention, more so the agricultural, domestic and hospital settings. Microbicides (e.g. disinfectants, antiseptics, fungicides, algaecides, insecticides and pesticides) are used rampantly to control undesirable microbes. Insecticides and pesticides are routinely used in agriculture which directly affect the microbial population in farms, orchards and fields. Health care environments are always stressed with disinfectants and antibiotics. It is always probable that microbicide-stressed microorganisms are in a dynamic state, displaced from one niche to the other. Some soil and water borne bacteria or their resistance determinants are also getting prominence in hospital settings after suffering selective pressure from agricides. In order to reveal the survival strategies of microbicidal-resistant microbes, it isof prime importance to know the mode of action of these complete range of microbicides (agricides to antibiotics). The present book intends to address these issues. There will be several chapters dealing with tolerance and cross resistance in microbes and bacteria in particular, dwelling in various niches. Till date, there is no consensus among scientists in theorizing molecular mechanisms to explain bacterial tolerance and their cross resistance to agricides and antibiotics.
