The Nociceptin/Orphanin FQ Peptide Receptor

The aim of this book is not only to introduce readers with a broad spectrum of biological actions of the NOP receptor, but also to feature a detailed look at the N/OFQ-NOP receptor system, medicinal chemistry, pharmacology, and clinical data of NOP-targeted ligands. This special volume book - for the first time focusing on the NOP receptor - is designed to serve as a useful reference, stimulate more research on the N/OFQ-NOP receptor system, and lead to more development of NOP-related ligands for several therapeutic applications.

List of contents

PART I. The N/OFQ-NOP Receptor System.- 1. The History of N/OFQ and the NOP Receptor.- 2. NOP-Targeted Peptide Ligands.- 3. NOP-Targeted Nonpeptide Ligands.- 4. Pharmacological Assays for Investigating the NOP Receptor.- 5. Electrophysiological Actions of N/OFQ.- 6. NOP Receptor Signaling Cascades.- 7.Regulation of the Genes Encoding the ppN/OFQ and NOP Receptor.- PART II. Biological Actions of NOP Ligands.- 8.NOP-Related Mechanisms in Pain and Analgesia.- 9. NOP-Related Mechanisms in Substance Use Disorders.- 10. NOP Receptor Ligands and Parkinson's Disease.- 11. NOP Ligands for the Treatment of Anxiety and Mood Disorders.- 12. The Nociceptin/Orphanin FQ System and the Regulation of Memory.- 13. N/OFQ-NOP System in Food Intake.- 14. N/OFQ-NOP System in Peripheral and Central Immunomodulation.- 15. N/OFQ-NOP System and Airways.- 16. Effects of NOP-Related Ligands in Nonhuman Primates.- PART III. First Clinical Studies with NOP Ligands.- 17. Nociceptin/Orphanin FQ and Urinary Bladder.- 18. Cebranopadol: A Novel First-in-Class Potent Analgesic Acting via NOP and Opioid Receptors.- 19. Therapeutic Approaches for NOP Receptor Antagonists in Neurobehavioral Disorders: Clinical Studies in Major Depressive Disorder and Alcohol Use Disorder with BTRX-246040 (LY2940094).- 20. Correction to: Electrophysiological Actions of N/OFQ.

Product details

• Assisted by: Girolamo Calo (Editor), Caló (Editor), Caló (Editor), Girolamo Caló (Editor), Mei-Chua Ko (Editor), Mei-Chuan Ko (Editor)
• Publisher: Springer, Berlin
• Languages: English
• Product format: Hardback
• Released: 01.01.2019
• EAN: 9783030201852
• ISBN: 978-3-0-3020185-2
• No. of pages: 417
• Dimensions: 162 mm x 242 mm x 30 mm
• Weight: 796 g
• Illustrations: X, 417 p. 78 illus., 21 illus. in color.
• Series: Handbook of Experimental Pharmacology
• Subjects: Natural sciences, medicine, IT, technology > Medicine > Pharmacy; Psychiatrie, B, Neurowissenschaften, Schmerz und Schmerztherapie, Anästhesiologie, Neuroscience, Psychiatry, Pain & pain management, Neurosciences, Pharmacology, Psychopharmacology, Biomedical and Life Sciences, Anesthesiology, Pain Medicine, Anaesthetics, Pharmacology/Toxicology