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The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses.
With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.
List of contents
The Natural History of Breast Cancer.- Perioperative Inflammation as Triggering Origin of Metastasis Development.- Peri-operative Shift in Angiogenesis-Related Factors in Breast Cancer Patients.- Perioperative Biologic Perturbation and Cancer Surgery: Targeting the adrenergic-inflammatory response and microcirculatory dysregulation.- Circulating tumor cells as predictive marker in metastatic disease.- Randomized Clinical Trials on Breast Cancer in Nigeria and other Developing Countries- Challenges and Constraints.- Do Breast Cancer Patients Benefit from Surgery? Hypotheses, Mathematical Models and False Beliefs.- The impact of wound inflammation on cancer progression; Studies in fish and patients.- Long term consequences of acute inflammation in cancer surgery: New findings and perspectives.- Cancer: Nurture and Nature.- The systemic effects of local treatments (surgery and radiotherapy) of breast cancer.
About the author
Michael Retsky, PhD, is Research Associate, Harvard TH Chan School of Public Health and Honorary Faculty, University College London
Romano Demicheli, MD, PhD, is Senior Researcher, Istituto Nazionale Tumori di Milano
Summary
The book will explain previously unconnected clinical data such as why mammography works better for women age 50-59 than it does for women age 40-49, why adjuvant chemotherapy works best for premenopausal patients with positive lymph nodes, and it may also explain the racial disparity in outcome. In particular, it points to the perioperative period when systemic inflammation persists for a week or so. This can lead to a variety of mechanisms whereby single cancer cells (perhaps from the marrow) begin division and angiogenesis of dormant avascular micrometastases occurs leading to early relapses.
With chapters presented from distinguished scientists and physicians in a variety of specialties that relate to and border the effects we present, this volume can be used as a reference for practicing physicians and as a jumping-off point for researchers to explore new therapeutic opportunities.
