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Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods - both well established and recently introduced - in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists .
List of contents
Assessment Of Drug Penetration Enhancement.- Basic Mathematics.- Influence Of Occlusive Versus Non-Occlusive Application Conditions.- Finite Dose Versus Infinite Dose.- Prediction Of Skin Absorption From Complex Formulations.- Mechanistic Studies Of Permeation Enhancers.- High Throughput Screening.- Corneoxenometry.- Tape-Stripping.- Epr In Determing Drug Penetration.- Raman Spectroscopy.- Atr-Ftir.- Confocal Laser Scanning Microscopy.- The Use Of Skin Alternatives For Testing Percutaneous Penetration.- Human Native And Reconstructed Skin Preparations For In-Vitro Penetration And Permeations Studies.- Novel Approaches To The Design And Development Of Functional Human Skin.- The Retardation Of Percutaneous Penetration.- Retardation Strategies For Sunscreen Agents.- Military Perspectives In Chemical Penetration Retardation.- Patent Overview Of Penetration Enhancers.- Patent Overview Of Enhancement Techniques.- Safety And Ethics.- Research Ethics.- Current Status Of Dermal And TransdermalDrug Delivery.
About the author
Howard I. Maibach is Professor of Dermatology at the University of California, San Francisco. He is a leading authority in the fields of dermatotoxicology and dermatopharmacology, in which he has conducted much original research and written very extensively, with a total of more than 2,500 publications as lead or co-author. Professor Maibach has served on the editorial boards of more than 30 scientific journals and is a member of many professional societies, including the American Academy of Dermatology and the International Commission on Occupational Health. He has also been the recipient of numerous honors, both within the United States and overseas. Nina Dragićević-Ćurić graduated from the University of Belgrade, Faculty of Pharmacy in 1999 and subsequently obtained an MSc and a PhD (summa cum laude, Dr. rer. nat.) in Pharmaceutical Technology from the University of Belgrade and the Friedrich-Schiller University, Jena, respectively. Dr. Dragićević-Ćurić is an accredited Specialistin Pharmaceutical Technology. Since 2007 she has been responsible for the preparation of compounded drugs in pharmacies of the state pharmaceutical company “Apoteka Beograd” in Belgrade. She has published in a variety of international journals.
Summary
Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists.
