Anti-Fibrotic Drug Discovery

Klappentext Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology. Zusammenfassung Anti-fibrotic Drug Discovery is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver! kidney! heart and lung disease! in which fibrosis plays a key role in pathology. Inhaltsverzeichnis TGFß Signaling; Targeting the av Integrins in Fibroproliferative Disease; Discovery, Structural Refinement and Therapeutic Potential of Farnesoid X Receptor Activators; Autotaxin Inhibitors in Fibrosis; Inhibition of LOXL2 and Other Lysyl Oxidase (Like) Enzymes: Intervention at the Core of Fibrotic Pathology; Targeting the Ubiquitin Proteasome System in Pulmonary Fibrosis; Galectin-3 Involvement in Fibrotic Diseases; Emerging Role of CXCR4 in Fibrosis; BH3 Mimetic Drugs for Anti-fibrotic Therapy; Intratumoral Fibrosis: Emerging Concepts and Therapeutic Opportunities; Targeting Fibroblasts in Fibrosis and Cancer

Product details

• Authors: Jehrod (KSQ Therapeutics Brenneman
• Assisted by: Jehrod Brenneman (Editor), Jehrod (KSQ Therapeutics Brenneman (Editor), Malliga Iyer (Editor), Malliga R Iyer (Editor), Malliga R (National Institutes of Health Iyer (Editor), Malliga R. Iyer (Editor)
• Publisher: Royal Society Of Chemistry
• Languages: English
• Product format: Hardback
• Released: 31.03.2020
• EAN: 9781788015103
• ISBN: 978-1-78801-510-3
• No. of pages: 356
• Series: Drug Discovery; Drug Discovery; Drug Discovery Series; ISSN
• Subjects: Natural sciences, medicine, IT, technology > Chemistry > Organic chemistry; Organische Chemie, SCIENCE / Chemistry / Organic, MEDICAL / Pharmacology, Medical / Nursing